Subcutaneous Panniculitis-Like T-Cell Lymphoma in Children: A Review of the Literature

Pediatric Dermatology
Zhi Li HuZongHui Li

Abstract

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a type of skin lymphoma. Pleomorphic T-cells infiltrate the subcutaneous tissue and mimic lobular panniculitis. We report a case occurring in a 12-year-old Chinese boy who presented with multiple indolent erythematous subcutaneous nodules on both extremities without systemic symptoms. He had a protracted course of multiple erythematous subcutaneous nodules for 1 year and underwent biopsy of lesional skin for histology and T-cell receptor (TCR) gene analysis. Histopathology showed infiltration of medium to large atypical pleomorphic cells involving the subcutis with characteristic rimming of fat spaces. TCR gene rearrangement shows monoclonal rearrangements of the TCR β and γ chains. Immunophenotypic studies showed that CD3, CD4, and CD8 were strongly and diffusely positive in lesional cells and that CD56 was focally positive. In contrast, these cells were negative for CD20, CD30, and CD68. The combined morphology, characteristic histologic features, and positive T-CR gene rearrangement supported a diagnosis of SPTCL. He is being treated with combination chemotherapy of cyclophosphamide, doxorubicin, vincristine, and prednisolone.

References

Feb 25, 1999·Journal of Pediatric Hematology/oncology·I J HungC F Sun
Dec 18, 2001·Medical and Pediatric Oncology·A B ThomsonW H Wallace
Jan 17, 2004·Journal of the American Academy of Dermatology·Ayelet Shani-AdirAmy S Paller
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Nov 30, 2011·Pediatric Dermatology·Yasuhiro KawachiFujio Otsuka
Jan 1, 2011·Case Reports in Oncological Medicine·Achiléa L BittencourtIguaracyra Araujo
Jul 23, 2013·Pediatric Blood & Cancer·Brian Y MerrittCholadda V Curry

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Citations

Mar 19, 2016·British Journal of Haematology·Vinodh PillaiMegan S Lim
Dec 15, 2017·Journal of Pediatric Hematology/oncology·Maria E GuerzoniLorenzo Iughetti
Dec 7, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Hironori GotoKenji Ihara
Oct 6, 2018·Indian Journal of Dermatology, Venereology and Leprology·Chandra Sekhar SirkaDebjani Panda
Aug 28, 2020·Journal of Pediatric Hematology/oncology·Geoffrey A SmithMichelle L Hermiston
Nov 20, 2021·The American Journal of Dermatopathology·Eduardo Marín-HernándezIlse Y Osorio-Aragón

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