Subcutaneous phaeohyphomycotic cyst caused by Pyrenochaeta romeroi

Medical Mycology
H BadaliG S de Hoog

Abstract

Pyrenochaeta romeroi is a rare agent of chronic, suppurative subcutaneous infections which ultimately lead to mycetoma. It has only rarely been reported from deep, non-mycetomatous infections. We describe a case of a subcutaneous phaeohyphomycotic cyst in a 45-year-old Indian female who suffered from verrucous plaque and a swelling (30 mm in diameter) on the right forearm that gradually increased in size over a period of 3 months. Direct microscopic examination with 10% KOH and histopathological investigation of exudates revealed septate hyphae without granules, the hallmark of mycetoma. The lesion appeared to be a subcutaneous phaeohyphomycotic cyst caused by P. romeroi. The suspected agent was recovered in culture, identified on the basis of morphologic features and its identification confirmed by sequencing of the internal transcribed spacer regions of rDNA. Treatment consisted of surgical excising of the cyst without any antifungal therapy. There was no relapse during a one-year follow-up and the patient was successfully cured. In vitro antifungal susceptibility tests demonstrated that itraconazole (0.5 microg/ml), isavuconazole (0.125 microg/ml) and posaconazole (0.5 microg/ml) had potent activity against this isolate of P...Continue Reading

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Citations

Sep 16, 2011·Journal of Medical Case Reports·Umasankar Mathuram ThiyagarajanMichael L Nicholson
Apr 26, 2014·Singapore Medical Journal·Yuen Yue Candice ChanBan Hock Tan
Sep 10, 2013·Studies in Mycology·J de GruyterP W Crous
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May 6, 2015·Medical Mycology Case Reports·Sarita YadavShikha Goel
Jan 30, 2015·Medical Mycology·Sarah Abdalla AhmedWendy W J van de Sande
Jun 28, 2014·Medical Mycology·Sarah A AhmedG S de Hoog
Feb 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A ChowdharyM Cuenca-Estrella
May 20, 2016·Mycopathologia·Alireza AbdolrasouliElizabeth M Johnson
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Sep 16, 2016·Frontiers in Microbiology·Aurélien DinhNawel Ait Ammar
Mar 14, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ibai Los-ArcosOscar Len

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