PMID: 3214661Jul 1, 1988Paper

Subcutaneous polymeric matrix system p(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). II: Release kinetics

Biomaterials
A DenizliE Pişkin

Abstract

A subcutaneous polymeric drug delivery system, which consists of a polymeric matrix of poly(hydroxyethyl methacrylate-bisglycol acrylate), was developed. 5-fluorouracil was used as the model anticancer drug. Polymer-drug beads with a diameter of 3 mm were prepared by low-temperature radiation polymerization. In order to modify the release rate, polymeric beads with different composition, drug loading and crosslinking density were obtained. The kinetics of drug release were described by the expression Mt/M infinity = ktn. The diffusional release exponent 'n', which was calculated from the release curves, indicated that the mechanism of drug release from the polymeric matrix is due to the anomalous (non-Fickian) type of diffusion.

References


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Citations

Nov 1, 1994·Biomaterials·R M TrigoR Sastre
Apr 21, 1995·Journal of Chromatography. B, Biomedical Applications·A Denizli, E Pişkin
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·M Kiremitçi-GümüşdereliogluR F Akata
Feb 29, 2000·International Journal of Pharmaceutics·L FerreiraM H Gil
Oct 31, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Müge Andaç
Jan 1, 1993·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·A DenizliE Pişkin
Aug 14, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Deniz TürkmenAdil Denizli
Jan 1, 1990·Biomaterials, Artificial Cells, and Artificial Organs·M Kiremitçi, E Pişkin
Jan 21, 2015·Colloids and Surfaces. B, Biointerfaces·Kemal Çetin, Adil Denizli
Oct 3, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José L Arias
Jan 21, 2017·Journal of Biomaterials Science. Polymer Edition·Pınar ÖncelAdil Denizli
Oct 3, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takeo ItoSei-ichi Nishimoto
May 17, 1996·Journal of Chromatography. B, Biomedical Applications·M D BlancoI Katime

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