Subdural hematoma following traumatic brain injury causes a secondary decline in brain free magnesium concentration

Journal of Neurotrauma
D L Heath, Robert Vink

Abstract

A number of studies have demonstrated that neurologic motor and cognitive deficits induced by traumatic brain injury (TBI) can be attenuated with administration of magnesium salts. However, many severe traumatic brain injuries have a significant hematoma that develops subsequent to the primary events, and it is unclear whether magnesium salts are effective in this situation. In the present study, an impact-acceleration rodent model of TBI was used to produce an injury that causes an extensive subdural hematoma in over 50% of injured animals. At 30 min after TBI, rats were randomly administered 250 micromoles/kg intravenous MgSO4 or equal volume saline before being monitored by magnetic resonance spectroscopy for 8 h to determine brain intracellular free magnesium concentration. Animals were then assessed for neurologic motor deficits over 1 week using a rotarod device, followed by postmortem examination for presence of subdural hematoma. Animals with subdural hematoma treated with MgSO4 showed no improvement in motor outcome when compared to nontreated controls. Animals with no visible subdural hematoma demonstrated a significant improvement (p < 0.05 by ANOVA) in rotarod scores with MgSO4 treatment. Brain free magnesium concen...Continue Reading

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Citations

Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Robert Vink, Alan J Nimmo
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ananda P Sen, Anil Gulati
Oct 7, 2004·Journal of the American College of Nutrition·Renee J TurnerRobert Vink
Jan 26, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·JoAnne E NataleDonald H Shaffner
Jun 3, 2009·Neurosurgery·David C VianoAnnette Säljö
Jan 4, 2013·PloS One·Dasuni S AlwisRamesh Rajan
Oct 6, 2004·Expert Opinion on Investigational Drugs·Robert Vink, Corinna Van Den Heuvel
Sep 3, 2004·Neuroscience and Biobehavioral Reviews·Scott T FujimotoTracy K McIntosh

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.