Subdural hematomas during CML therapy with imatinib mesylate

Leukemia & Lymphoma
K W SongJ H Lipton

Abstract

Seven of one hundred twenty-one patients with chronic myeloid leukemia (CML) treated with imatinib mesylate developed subdural hematomas. All had advanced disease and were treated initially at a dose of 600 mg per day. Three patients had thrombocytopenia (platelet < 10 x 10(9)/l), one had leukocytosis (white blood cell count > 150 x 10(9)/l) and three had neither around the time of diagnosis of the subdural hematomas. Four patients required surgical evacuation. One patient, in blast crisis, died as a consequence of the subdural hematoma. Three patients survived but died of progressive CML. The remaining three patients having recommenced imatinib, are alive and well, and one has achieved a major cytogenetic response. Subdural hematomas must be considered even in mildly symptomatic patients receiving imatinib regardless of their peripheral blood counts. Patients who survive can be cautiously restarted on imatinib. Further studies are required to study the potential relationship between imatinib mesylate and subdural hematomas.

References

Apr 1, 1988·Cancer·H M KantarjianE J Freireich
Apr 29, 1999·The New England Journal of Medicine·C L Sawyers
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Mar 1, 2002·The New England Journal of Medicine·Hagop KantarjianUNKNOWN International STI571 CML Study Group
Mar 1, 2002·The New England Journal of Medicine·Michelle A ElliottAyalew Tefferi
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu

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Citations

Nov 26, 2013·Rheumatic Diseases Clinics of North America·Saman Ahmed, Harold I Palevsky
Jul 27, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adaani E FrostHossein-Ardeschir Ghofrani
Aug 23, 2005·Cancer Chemotherapy and Biological Response Modifiers·Peter H Wiernik
May 11, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Caitlin E O'BrienJean-Marc Voyadzis
Mar 10, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Luis Felipe Lopes PradaRogério Souza
Oct 3, 2006·American Journal of Hematology·Upendra SrinivasRenu Saxena
Aug 27, 2009·Nature Reviews. Clinical Oncology·David SchiffMartin J van den Bent
Jun 29, 2010·Journal of Neuro-oncology·Mohamed M AbdulhamidWalter A Hall
Oct 30, 2018·Journal of Cerebrovascular and Endovascular Neurosurgery·Sooji SirhSukh Que Park
Nov 13, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ankur JainSumita Saluja

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