Subepithelial Corneal Deposits Associated with Exemestane

Case Reports in Ophthalmological Medicine
Annahita AmireskandariThomas Mauger

Abstract

This is a case report of corneal deposits noted in a 69-year-old female patient taking the aromatase inhibitor, exemestane, after undergoing a mastectomy and chemotherapy for breast cancer. The patient presented to our eye clinic for a new-onset floater in one eye, and bilateral subepithelial opacities were found incidentally on exam. The patient completed a 5-year course of the medication shortly after her initial visit with us and was noted to have a slight improvement in the density of the opacities on a follow-up visit 3 months later. We believe these corneal changes were most likely secondary to exemestane. The effect of aromatase inhibitors on the eye deserves further exploration as an increasing number of patients are prescribed these medications.

References

Dec 24, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L S HofstraP H Willemse
Jun 13, 2001·Current Eye Research·T SuzukiS Kinoshita
Jun 26, 2001·The British Journal of Ophthalmology·C MunautJ M Rakic
Jul 16, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Piera Versura, Emilio C Campos
Sep 1, 2005·Journal of Neuro-oncology·V ScaioliG Luca
Sep 16, 2006·Eye & Contact Lens·Orkun MuftuogluAyfer Kanpolat
Dec 13, 2006·American Journal of Ophthalmology·Jean Y ChuoDavid A L Maberley
May 16, 2007·Archives of Ophthalmology·Mandar M Joshi, Bruce R Garretson
May 14, 2008·Molecular Medicine·Rinki RayDaniel R Meldrum
Aug 21, 2008·Breast Cancer Research and Treatment·Alvin EisnerJohn T Vetto
Mar 24, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael UntchGunter von Minckwitz
May 18, 2010·Cutaneous and Ocular Toxicology·Miltiadis PapathanassiouIoannis Vergados
May 25, 2010·Breast Cancer Research and Treatment·Rebecca L Sedjo, Scott Devine
Dec 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard A BurrisJoyce A O'Shaughnessy
Dec 22, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Samantha B WangKarsten Gronert
Feb 23, 2012·Seminars in Ophthalmology·Sonali TarafdarKanna Ramaesh
Sep 11, 2012·Clinical & Experimental Ophthalmology·Kiran TurakaChristopher J Rapuano
Oct 1, 2015·The Breast : Official Journal of the European Society of Mastology·Holly InglisStephanie L Watson
Jun 15, 2016·The Breast Journal·Irini ChatziralliMarilita Moschos
Nov 2, 2019·The Ocular Surface·Emma GibsonBlanka Golebiowski
Apr 29, 2020·The Ocular Surface·Jeremy Chung Bo ChiangKatie Edwards

❮ Previous
Next ❯

Citations

Apr 1, 2021·Drugs·Blake H FortesLauren A Dalvin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Opinion on Drug Metabolism & Toxicology
P E Lønning, Jürgen Geisler
Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Makoto TaharaMunehiro Hashimoto
Nederlands tijdschrift voor geneeskunde
Helena M VerkooijenPetra H M Peeters
© 2021 Meta ULC. All rights reserved