Subfertility among HIV-affected couples in a safer conception cohort in South Africa

American Journal of Obstetrics and Gynecology
Jessica R IyerSheree R Schwartz

Abstract

Subfertility among couples affected by HIV has an impact on the well-being of couples who desire to have children and may prolong HIV exposure. Subfertility in the antiretroviral therapy era and its determinants have not yet been well characterized. The objective of the study was to investigate the burden and determinants of subfertility among HIV-affected couples seeking safer conception services in South Africa. Nonpregnant women and male partners in HIV seroconcordant or HIV discordant relationships desiring a child were enrolled in the Sakh'umndeni safer conception cohort at Witkoppen Clinic in Johannesburg between July 2013 and April 2017. Clients were followed up prospectively through pregnancy (if they conceived) or until 6 months of attempted conception, after which they were referred for infertility services. Subfertility was defined as not having conceived within 6 months of attempted conception. Robust Poisson regression was used to assess the association between baseline characteristics and subfertility outcomes; inverse probability weighting was used to account for missing data from women lost to safer conception care before 6 months of attempted conception. Among 334 couples enrolled, 65% experienced subfertility ...Continue Reading

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Citations

Jun 26, 2021·The World Journal of Men's Health·Nahid PunjaniPhilip S Li
Sep 4, 2021·HIV Medicine·Anna HachfeldUNKNOWN Swiss HIV Cohort Study, the Swiss Mother, Child HIV Cohort Study (MoCHiV)

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