Subfoveal Choroidal Thickness Changes Following Anti-Vascular Endothelial Growth Factor Therapy in Myopic Choroidal Neovascularization

Investigative Ophthalmology & Visual Science
Seong Joon AhnSe Joon Woo

Abstract

To investigate subfoveal choroidal thickness (SFCT) changes following intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy and to identify clinical and choroidal parameters associated with visual outcome in eyes with myopic choroidal neovascularization (CNV). In 60 eyes of 54 patients who were treated with anti-VEGF injections for myopic CNV, SFCT was measured using enhanced depth imaging optical coherence tomography at baseline, at 1, 3, and 6 months after initial anti-VEGF therapy, and at the final visit. Subfoveal choroidal thickness was compared between visits in subgroups separated based on anatomic outcome, recurrence, or resolution. Univariate and multivariate regression analyses were performed to identify factors associated with final best-corrected visual acuity (BCVA). At baseline, the mean SFCT was 47.6 ± 24.7 μm, significantly lower than that of the contralateral eyes (59.8 ± 34.4 μm, P = 0.022). The thickness significantly decreased to 45.2 ± 24.0 μm (P = 0.027) 1 month after the anti-VEGF therapy. In the recurrent cases, the SFCT significantly increased from 46.1 ± 25.5 μm at month 1 to 52.4 ± 25.8 μm at the time of recurrence (P = 0.020); however, no significant change in the SFCT was noted in...Continue Reading

Citations

Jul 2, 2016·Drugs·Kelvin Yi Chong TeoChui Ming Gemmy Cheung
Oct 24, 2017·Asia-Pacific Journal of Ophthalmology·Danny S C NgKyoko Ohno-Matsui
Aug 4, 2018·Investigative Ophthalmology & Visual Science·Alessandro InvernizziFrancesco Viola
Sep 27, 2018·Asia-Pacific Journal of Ophthalmology·Tae Yokoi, Kyoko Ohno-Matsui
Apr 30, 2020·European Journal of Ophthalmology·Chiara GiuffrèGiuseppe Querques
Apr 30, 2021·The British Journal of Ophthalmology·Shiqi XieKyoko Ohno-Matsui

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