Subfoveal choroidal thickness in polypoidal choroidal vasculopathy after switching to intravitreal aflibercept injection

Japanese Journal of Ophthalmology
Masaaki SaitoTetsuju Sekiryu

Abstract

To investigate the changes in subfoveal thickness after switching to intravitreal aflibercept injection for polypoidal choroidal vasculopathy (PCV). We retrospectively reviewed 66 eyes of 65 PCV patients (mean age 75.7 years) which were refractory to ranibizumab. The choroidal thickness was measured by optical coherence tomography (OCT) using an enhanced depth imaging technique. Intravitreal aflibercept (2 mg/0.05 ml) was administered with three consecutive monthly injections as a loading dose, followed by further injections bimonthly (every two months). The mean subfoveal choroidal thickness significantly decreased from 203 μm at baseline to 171 μm at month 6 (P < 0.0001). The mean logMAR best-corrected visual acuity levels significantly improved from 0.40 at baseline to 0.33 at 6 months (P < 0.001). The central retinal thickness significantly decreased from 249 μm at baseline to 161 μm at 6 months (P < 0.0001). At month 6, 41 (62.1%) eyes had dry macula by OCT. Of 46 eyes with polypoidal lesions at baseline, complete regression of polypoidal lesions was achieved in 26 (56.5%) eyes at 3 months. The choroidal thickness in PCV eyes significantly decreased after switching to intravitreal aflibercept injection. Aflibercept may hel...Continue Reading

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Citations

Sep 24, 2016·Japanese Journal of Ophthalmology·Masaaki SaitoTetsuju Sekiryu
Sep 25, 2016·Japanese Journal of Ophthalmology·Wataru KikushimaHiroyuki Iijima
Oct 5, 2016·Japanese Journal of Ophthalmology·Munemitsu YoshikawaNagahisa Yoshimura
Oct 26, 2018·Japanese Journal of Ophthalmology·Shozo SonodaTaiji Sakamoto
Jan 13, 2017·International Journal of Retina and Vitreous·Prateep PhadikarDean Eliott
Dec 26, 2017·Current Ophthalmology Reports·Joon-Bom KimAjay E Kuriyan
Dec 23, 2017·Japanese Journal of Ophthalmology·Shozo SonodaEisuke Uchino
Oct 8, 2018·Japanese Journal of Ophthalmology·Hideki ShiiharaTaiji Sakamoto
May 4, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jae Hui KimDong Won Lee
Jun 27, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hideki ShiiharaShozo Sonoda
Dec 2, 2020·Acta Ophthalmologica·Shyamanga BorooahDhiren Bujarborua
Aug 28, 2019·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Eun Young ChoiChristopher Seungkyu Lee

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