Subfunction partitioning, the teleost radiation and the annotation of the human genome

Trends in Genetics : TIG
John PostlethwaitYi-Lin Yan

Abstract

Half of all vertebrate species are teleost fish. What accounts for this explosion of biodiversity? Recent evidence and advances in evolutionary theory suggest that genomic features could have played a significant role in the teleost radiation. This review examines evidence for an ancient whole-genome duplication (tetraploidization) event that probably occurred just before the teleost radiation. The partitioning of ancestral subfunctions between gene copies arising from this duplication could have contributed to the genetic isolation of populations, to lineage-specific diversification of developmental programs, and ultimately to phenotypic variation among teleost fish. Beyond its importance for understanding mechanisms that generate biodiversity, the partitioning of subfunctions between teleost co-orthologs of human genes can facilitate the identification of tissue-specific conserved noncoding regions and can simplify the analysis of ancestral gene functions obscured by pleiotropy or haploinsufficiency. Applying these principles on a genomic scale can accelerate the functional annotation of the human genome and understanding of the roles of human genes in health and disease.

References

Jul 7, 1995·Journal of Theoretical Biology·G J Graham
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S AparicioS Brenner
Mar 1, 1994·Molecular Phylogenetics and Evolution·D Larhammar, C Risinger
Apr 16, 1998·Nature Genetics·J H PostlethwaitW S Talbot
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·M R RebagliatiI B Dawid
Sep 12, 1998·Science·G Vogel
Sep 23, 1998·Nature·P Blader, U Strähle
Nov 30, 1998·Science·A AmoresJ H Postlethwait
Nov 30, 1998·Mechanisms of Development·S NornesT Johansen
May 13, 1999·Nature Genetics·W BiB de Crombrugghe
Jul 27, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A C OatesA F Wilks
Aug 12, 1999·Journal of Molecular Evolution·A Stoltzfus
Dec 22, 1999·Seminars in Cell & Developmental Biology·S Ohno
Feb 1, 2000·Trends in Genetics : TIG·S Aparicio
Mar 31, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S de MartinoC A Austin
Sep 14, 2000·Genome Research·W B BarbazukS L Johnson
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·M B HawkinsP Thomas
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·B S Gaut, J F Doebley
Dec 16, 2000·Genome Research·J H PostlethwaitW S Talbot
Dec 16, 2000·Genome Research·I G WoodsW S Talbot
Apr 28, 2001·Biological Reviews of the Cambridge Philosophical Society·R Phillips, P Ráb
May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·W BiB de Crombrugghe
May 30, 2001·Trends in Genetics : TIG·J S TaylorA Meyer
Oct 18, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J S TaylorA Meyer
Dec 26, 2001·Nucleic Acids Research·Yves Van de PeerAxel Meyer
Feb 2, 2002·Nature Reviews. Genetics·Joachim WittbrodtManfred Schartl
Jul 27, 2002·Science·Samuel AparicioSydney Brenner
Dec 10, 2002·Molecular Phylogenetics and Evolution·Jun G InoueMutsumi Nishida
Dec 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Annamaria LocascioM Angela Nieto

❮ Previous
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Citations

Jun 13, 2014·PloS One·Tatjana SkoboLuisa Dalla Valle
Jun 30, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Kavarthapu Raghuveer, Balasubramanian Senthilkumaran
Feb 4, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ingo BraaschJohn H Postlethwait
Jun 25, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kevin VannesteYves Van de Peer
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Steven MaereYves Van de Peer
Aug 6, 2014·Molecular Genetics and Genomics : MGG·Stella M K Glasauer, Stephan C F Neuhauss
Aug 20, 2005·Genome Research·Ian G WoodsWilliam S Talbot
Jun 22, 2006·BMC Cell Biology·A Paul MouldMartin J Humphries
Aug 8, 2006·BMC Genomics·Jean-Marc CorsiHervé Enslen
Feb 17, 2007·BMC Evolutionary Biology·Edna C Suárez-Castillo, José E García-Arrarás
May 15, 2007·BMC Evolutionary Biology·Ingo BraaschJean-Nicolas Volff
Aug 19, 2007·BMC Evolutionary Biology·Simone Hoegg, Axel Meyer
Feb 9, 2008·Endocrinology·Deanna L HowarthSeth W Kullman
Feb 12, 2008·BMC Evolutionary Biology·Frédéric J J ChainBen J Evans
Feb 20, 2008·PLoS Genetics·Dirk A KleinjanPedro Coutinho
May 9, 2008·Genome Research·Jae-Il ParkSheau Yu Teddy Hsu
Oct 7, 2008·Briefings in Functional Genomics & Proteomics·Harold A Burgess, Michael Granato
Feb 20, 2009·Theory in Biosciences = Theorie in Den Biowissenschaften·Karen E ChambersChi-hua Chiu
Mar 18, 2009·Journal of Biology·Ingo Braasch, Walter Salzburger
Mar 27, 2009·Molecular Biology and Evolution·Kevin N RohmannAndrew H Bass
May 26, 2009·Genome Research·Julian M CatchenJohn H Postlethwait
Jun 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew J JennyMark E Hahn
Jun 19, 2009·BMC Neuroscience·Junji ItouTakashi Kawasaki
Jun 26, 2009·Development·Nikolas NikolaouDavid G Wilkinson
Dec 4, 2009·PLoS Biology·Nicole L WashingtonSuzanna E Lewis
Jan 19, 2010·Genes & Development·Dorothy F SobieszczukDavid G Wilkinson
Jan 29, 2010·BMC Evolutionary Biology·Juliette A G C LaisneyManfred Schartl

❮ Previous
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