Subgenual Cingulate-Amygdala Functional Disconnection and Vulnerability to Melancholic Depression

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Clifford I WorkmanRoland Zahn

Abstract

The syndromic heterogeneity of major depressive disorder (MDD) hinders understanding of the etiology of predisposing vulnerability traits and underscores the importance of identifying neurobiologically valid phenotypes. Distinctive fMRI biomarkers of vulnerability to MDD subtypes are currently lacking. This study investigated whether remitted melancholic MDD patients, who are at an elevated lifetime risk for depressive episodes, demonstrate distinctive patterns of resting-state connectivity with the subgenual cingulate cortex (SCC), known to be of core pathophysiological importance for severe and familial forms of MDD. We hypothesized that patterns of disrupted SCC connectivity would be a distinguishing feature of melancholia. A total of 63 medication-free remitted MDD (rMDD) patients (33 melancholic and 30 nonmelancholic) and 39 never-depressed healthy controls (HC) underwent resting-state fMRI scanning. SCC connectivity was investigated with closely connected bilateral a priori regions of interest (ROIs) relevant to MDD (anterior temporal, ventromedial prefrontal, dorsomedial prefrontal cortices, amygdala, hippocampus, septal region, and hypothalamus). Decreased (less positive) SCC connectivity with the right parahippocampal ...Continue Reading

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Citations

Jul 18, 2020·The Journal of Comparative Neurology·Samantha M CalderazzoMaria Medalla
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Jul 13, 2021·NeuroImage·Olivia K HarrisonRobert L Barry
Dec 14, 2021·Frontiers in Psychiatry·Paul Rossener RegoniaJunichiro Yoshimoto

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