PMID: 9167091Jan 1, 1997Paper

Subgingival delivery of therapeutic agents in the treatment of periodontal diseases

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
W A Soskolne

Abstract

This article reviews the current status of controlled local delivery of antibacterial agents in the treatment of periodontitis. The principle of local intrapocket delivery of antibacterial agents and their delivery are discussed. The dosage forms include fibers, film/slabs, and injectable systems, some of which are degradable, while others are not and need to be removed at the termination of the treatment. The antibacterial agents used cover a range of antibiotics as well as antiseptics, and the composition of the delivery systems, their reported use, and the clinical results are summarized. The use of these systems in clinical practice is relatively recent, and therefore their application and integration into the dental office are not yet clearly defined. Clinical applications that have been tested are critically reviewed, and clinical situations in which controlled delivery of antibacterial agents may prove to be clinically useful are suggested for scientific evaluation.

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Citations

Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·A Hatefi, B Amsden
Nov 26, 2002·Journal of Clinical Periodontology·Daniela C GrisiMárcio F M Grisi
Apr 20, 2000·Journal of Clinical Pharmacy and Therapeutics·S P VyasV Mishra
Feb 4, 2009·Journal of Periodontology·Yael ShifrovitchMeital Zilberman
Jul 10, 2014·Drug Delivery·Deeksha JoshiGoutam Rath
Jan 10, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Markus ReiseBernd W Sigusch
Sep 16, 2008·Drug Discovery Today·Nilu JainRoop K Khar
Jul 25, 2008·Journal of Clinical Periodontology·Yael Houri-HaddadWilfred Aubrey Soskolne
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·W J Loesche
Feb 24, 2000·Journal of Periodontal Research·W L Murphy, D J Mooney
Jan 16, 2020·Brazilian Oral Research·Vivianne Carvalho da Cunha TrajanoMaria Esperanza Cortés
Mar 6, 2013·Implant Dentistry·Priscila Ladeira CasadoMaria Eugenia Leite Duarte
Nov 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eliseu A MünchowMarco C Bottino
Jul 1, 2020·International Journal of Biological Macromolecules·Elaheh FakhriHossein Samadi Kafil
Mar 25, 2021·Expert Opinion on Drug Delivery·Anže ZidarŠpela Zupančič
May 28, 2021·European Journal of Dentistry·Sirorat WacharanadIchaya Yiemwattana

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