Subgingival distribution of periodontopathic bacteria in adult periodontitis and their susceptibility to minocycline-HCl

Journal of Periodontology
S HagiwaraM Umeda

Abstract

The purpose of this study was to investigate the distribution of several periodontopathic bacteria in adult periodontitis, their in vitro susceptibility to minocycline-HCl, and whether the efficacy of the drug changes with a decrease in bacterial susceptibility. Twenty-one patients (43 to 75 years old) with 62 periodontal lesions from pockets > or =4 mm participated in the study. After subgingival sampling, an ointment containing 2% minocycline-HCl was applied locally to the selected pockets once a week for 4 weeks. The lesions were clinically examined after 1 and 4 weeks of administration. The distribution of the subgingival microorganisms included Capnocytophaga sputigena (37.1%), Prevotella intermedia (22.6%), Porphyromonas gingivalis (22.6%), Fusobacterium nucleatum (20.1%), Actinobacillus actinomycetemcomitans (9.7%), and Eikenella corrodens (4.8%). The distribution was complex, with 76.8% of the sites containing 1 to 3 bacterial spieces. The minimum inhibitory concentration (MIC) of minocycline-HCl for each organism showed that most were inhibited by a minocycline-HCl concentration equal to or less than the MIC for reference strains. However, some clinical strains of Prevotella intermedia seemed to exihibit low susceptibi...Continue Reading

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Citations

Jun 21, 2005·Journal of Materials Science. Materials in Medicine·A C QueirozF J Monteiro
Dec 5, 1998·Journal of Clinical Periodontology·B N VandekerckhoveD van Steenberghe
Feb 7, 2001·Journal of Clinical Microbiology·M AlsinaJ Frias
Jul 31, 2003·Journal of Periodontology·Başak DoğanSirkka Asikainen
Jun 15, 2021·RSC Medicinal Chemistry·Kaitlind C HowardSylvie Garneau-Tsodikova

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