Subgroup analysis of East Asians in RAINBOW: A phase 3 trial of ramucirumab plus paclitaxel for advanced gastric cancer

Journal of Gastroenterology and Hepatology
Kei MuroAtsushi Ohtsu

Abstract

East Asia has higher gastric cancer incidence and mortality rates than other regions. We present a subgroup analysis of East Asians in the positive study RAINBOW. Patients with advanced gastric or gastroesophageal junction adenocarcinoma previously treated with platinum and fluoropyrimidine received ramucirumab 8 mg/kg or placebo on days 1 and 15 plus paclitaxel 80 mg/m(2) on days 1, 8, and 15 of a 28-day cycle. Of 665 intention-to-treat patients, 223 were East Asian. Median overall survival was 12.1 months for ramucirumab plus paclitaxel and 10.5 months for placebo plus paclitaxel (hazard ratio: 0.986, 95% confidence interval: 0.727-1.337, P = 0.929). Median progression-free survival was 5.5 months for ramucirumab plus paclitaxel and 2.8 months for placebo plus paclitaxel (hazard ratio: 0.628, 95% confidence interval: 0.473-0.834, P = 0.001). Objective response rates were 34% for ramucirumab plus paclitaxel and 20% for placebo plus paclitaxel. Grade ≥ 3 neutropenia (60% vs 28%) and leukopenia (34% vs 13%) were higher for ramucirumab plus paclitaxel. The rate of febrile neutropenia was low (4% vs 4%). Special interest adverse events included any grade bleeding/hemorrhage (55% vs 25%), proteinuria (27% vs 7%), and hypertension (...Continue Reading

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Citations

May 6, 2016·Expert Review of Clinical Pharmacology·Giuseppe AprileMario Scartozzi
Jan 6, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Li-Tzong ChenYoon-Koo Kang
Jun 22, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tae You KimAtsushi Ohtsu
Nov 29, 2017·The Cochrane Database of Systematic Reviews·Vincent T JanmaatManon Cw Spaander
Jul 14, 2018·Annals of Gastroenterological Surgery·Yoshihiro TanakaKazuya Yamaguchi
Jan 27, 2019·Immunotherapy·Farzaneh AfshariNima Rezaei
Oct 22, 2019·Experimental Hematology & Oncology·Julie H SelimChung-Tsen Hsueh
Aug 20, 2021·Expert Opinion on Therapeutic Targets·Esmat AbdiMohammad Hassan Esmailnejad
Oct 10, 2021·The Lancet. Gastroenterology & Hepatology·Harry H Yoon

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