Subharmonic microbubble emissions for noninvasively tracking right ventricular pressures.

American Journal of Physiology. Heart and Circulatory Physiology
J K DaveFlemming Forsberg

Abstract

Right heart catheterization is often required to monitor intra-cardiac pressures in a number of disease states. Ultrasound contrast agents can produce pressure modulated subharmonic emissions that may be used to estimate right ventricular (RV) pressures. A technique based on subharmonic acoustic emissions from ultrasound contrast agents to track RV pressures noninvasively has been developed and its clinical potential evaluated. The subharmonic signals were obtained from the aorta, RV, and right atrium (RA) of five anesthetized closed-chest mongrel dogs using a SonixRP ultrasound scanner and PA4-2 phased array. Simultaneous pressure measurements were obtained using a 5-French solid state micromanometer tipped catheter. Initially, aortic subharmonic signals and systemic blood pressures were used to obtain a calibration factor in units of millimeters of mercury per decibel. This factor was combined with RA pressures (that can be obtained noninvasively) and the acoustic data from the RV to obtain RV pressure values. The individual calibration factors ranged from -2.0 to -4.0 mmHg/dB. The subharmonic signals tracked transient changes in the RV pressures within an error of 0.6 mmHg. Relative to the catheter pressures, the mean errors...Continue Reading

References

Mar 1, 1977·IEEE Transactions on Bio-medical Engineering·W M Fairbank, M O Scully
Aug 11, 1985·The American Journal of Physiology·T A MarinoG Cooper
Jan 1, 1981·Medical & Biological Engineering & Computing·B Hök
Jan 21, 1995·BMJ : British Medical Journal·J M Bland, D G Altman
May 13, 1999·Ultrasound in Medicine & Biology·W T ShiB B Goldberg
Apr 13, 2004·Current Opinion in Cardiology·Michael C Fishbein, Jon Kobashigawa
Sep 29, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Marie-Theres KasimirWalter Klepetko
Aug 3, 2005·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Flemming ForsbergBarry B Goldberg
Oct 6, 2005·JAMA : the Journal of the American Medical Association·Monica R ShahRobert M Califf
Oct 15, 2005·Ultrasound in Medicine & Biology·Yaniv GanorEitan Kimmel
Aug 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Hannah Rose, Richard Venn
Oct 25, 2006·Circulation·Norbert F VoelkelUNKNOWN National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure
Aug 9, 2007·Circulation·Cristina CortinaFrancisco Fernández-Avilés
Feb 8, 2008·Ultrasound in Medicine & Biology·Per Christian Sontum
Dec 17, 2009·The Journal of the Acoustical Society of America·Klaus Scheldrup Andersen, Jørgen Arendt Jensen
Feb 16, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Victor Mor-AviJonathan R Lindner
Aug 11, 2010·Nature Reviews. Cardiology·Luc L Mertens, Mark K Friedberg
Aug 14, 2010·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Peter J A FrinkingMarcel Arditi
Apr 12, 2011·The Journal of the Acoustical Society of America·Amit KatiyarFlemming Forsberg
Sep 22, 2011·Physics in Medicine and Biology·Telli FaezNico de Jong

❮ Previous
Next ❯

Citations

Mar 4, 2014·Ultrasound in Medicine & Biology·Himanshu ShekharMarvin M Doyley
Dec 13, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ipshita GuptaFlemming Forsberg
Nov 19, 2020·Radiology·Fabian Kiessling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.