Subinhibitory antibiotic concentrations mediate nutrient use and competition among soil streptomyces

PloS One
Patricia Vaz JauriLinda L Kinkel

Abstract

Though traditionally perceived as weapons, antibiotics are also hypothesized to act as microbial signals in natural habitats. However, while subinhibitory concentrations of antibiotics (SICA) are known to shift bacterial gene expression, specific hypotheses as to how SICA influence the ecology of natural populations are scarce. We explored whether antibiotic 'signals', or SICA, have the potential to alter nutrient utilization, niche overlap, and competitive species interactions among Streptomyces populations in soil. For nine diverse Streptomyces isolates, we evaluated nutrient utilization patterns on 95 different nutrient sources in the presence and absence of subinhibitory concentrations of five antibiotics. There were significant changes in nutrient use among Streptomyces isolates, including both increases and decreases in the capacity to use individual nutrients in the presence vs. in the absence of SICA. Isolates varied in their responses to SICA and antibiotics varied in their effects on isolates. Furthermore, for some isolate-isolate-antibiotic combinations, competition-free growth (growth for an isolate on all nutrients that were not utilized by a competing isolate), was increased in the presence of SICA, reducing the p...Continue Reading

References

Nov 10, 2001·Archives of Microbiology·M G WatveB D Bhole
Dec 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ee-Been GohJulian Davies
Sep 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gregory L Challis, David A Hopwood
Nov 24, 2004·Molecular Microbiology·George StratigopoulosEric Cundliffe
Apr 2, 2005·Current Opinion in Microbiology·Mervyn J Bibb
Jan 20, 2006·Nature Chemical Biology·Alexa Price-WhelanDianne K Newman
Jan 21, 2006·Science·Vanessa M D'CostaGerard D Wright
Mar 1, 2006·International Journal of Medical Microbiology : IJMM·Grace YimJulian Davies
Mar 23, 2006·Journal of Industrial Microbiology & Biotechnology·Julian Davies
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·J F LinaresJ L Martinez
Apr 3, 2007·Applied and Environmental Microbiology·Erin A GontangPaul R Jensen
Apr 1, 2008·Current Opinion in Microbiology·Alicia Fajardo, José L Martínez
Jun 12, 2008·Annual Review of Microbiology·Ainslie E F LittleJo Handelsman
Aug 16, 2008·Microbial Ecology·Daniel SchlatterLinda Kinkel
Mar 3, 2009·Current Opinion in Microbiology·Elizabeth Anne Shank, Roberto Kolter
Jul 16, 2009·Environmental Microbiology·Rustam I Aminov
Aug 22, 2009·Current Opinion in Microbiology·Michael A Fischbach
Oct 13, 2009·Research in Microbiology·Lili R Mesak, Julian Davies
Dec 1, 2009·Nature Reviews. Microbiology·Michael E HibbingS Brook Peterson
Apr 15, 2010·Antonie van Leeuwenhoek·Vivian Miao, Julian Davies
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·Natalia SubrtJulian Davies
Jun 7, 2011·Annual Review of Phytopathology·Linda L KinkelDaniel C Schlatter
Jul 27, 2011·Chemical Reviews·Diego RomeroRoberto Kolter
Mar 9, 2013·Microbiology and Molecular Biology Reviews : MMBR·Gang LiuHuarong Tan

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Citations

Oct 6, 2015·Journal of Industrial Microbiology & Biotechnology·Michael J SmanskiLinda L Kinkel
Aug 5, 2015·The ISME Journal·Nastassia V PatinPaul R Jensen
Jan 10, 2016·Applied and Environmental Microbiology·Carlos A Ruiz-PérezMaría Mercedes Zambrano
Dec 18, 2016·Applied and Environmental Microbiology·Nastassia V PatinPaul R Jensen
Mar 4, 2014·FEMS Microbiology Ecology·Daniel C Schlatter, Linda L Kinkel
Jan 25, 2020·Molecular Microbiology·Gleb Pishchany, Roberto Kolter
Apr 12, 2019·Frontiers in Microbiology·José Pablo Dundore-AriasLinda L Kinkel
Jan 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Marie VasseMichael E Hochberg
Aug 28, 2020·Frontiers in Microbiology·Peter DeinesThomas C G Bosch
Jul 16, 2021·Journal of Applied Microbiology·Jenifer OssaiMadan K Kharel
Aug 21, 2021·The ISME Journal·Matthew Michalska-SmithLinda L Kinkel
Oct 26, 2021·Natural Product Reports·Marc G Chevrette, Jo Handelsman
Dec 2, 2021·Natural Product Reports·Jack A ConnollyRainer Breitling

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