PMID: 8972541Dec 1, 1996Paper

Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers

Psychopharmacology
R SoriaE D London

Abstract

The present study assessed the subjective and cardiovascular effects of intravenous nicotine in smokers and nonsmokers. Nonsmokers (n = 5) and smokers (n = 5) were administered a single dose of nicotine (0.75 or 1.5 mg) or saline on each of 3 days. The nicotine doses were given in ascending order in a double-blind fashion. Although smokers and nonsmokers manifested significant increases in systolic and diastolic blood pressure and heart rate 1 min after administration of all active test doses, the difference between peak heart rate and that measured at later times was greater in nonsmokers than in smokers. Nonsmokers and smokers also differed in subjective self-reports. In response to items on visual analogue scales indicative of positive effects (e.g., "good effects," "like drug," "use again," and "feel energetic"), smokers but not nonsmokers reported high scores (> 40) after nicotine injection. In addition, responses on the MBG and LSD subscales of the Addiction Research Center Inventory indicated that smokers experienced positive subjective effects after the test doses, whereas nonsmokers experienced disorientation. The fact that intravenous nicotine was not associated with positive subjective effects in nonsmokers indicates...Continue Reading

Citations

Jan 20, 2007·Psychopharmacology·Reuven DarHanan Frenk
Mar 9, 2000·Addictive Behaviors·A J Waters, S R Sutton
Apr 25, 2000·Drug and Alcohol Dependence·T Eissenberg, R L Balster
Dec 22, 2005·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Bethea A KleykampThomas Eissenberg
Feb 16, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mehmet SofuogluPeter Jatlow
May 5, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jack H MendelsonNancy K Mello
May 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mehmet SofuogluMarc Mooney
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·D E KeylerP R Pentel
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·T EissenbergM Likness
Feb 22, 2007·PloS One·Bernard Le FollSteven R Goldberg
Jul 28, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Irina EsterlisJulie K Staley
Oct 6, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg
Mar 15, 2014·BMJ : British Medical Journal·Ivan BerlinMarie-Laure Tanguy
Dec 29, 2000·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·J T Gire, T Eissenberg
Jan 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin P JensenMehmet Sofuoglu
Jan 22, 2013·Drug and Alcohol Dependence·Emily M JutkiewiczJames H Woods
Oct 20, 2009·Hormones and Behavior·Nancy K Mello
Apr 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Aimee C RuscioAndrew J Waters
Nov 3, 2010·Neuroscience and Biobehavioral Reviews·Eoin C O'ConnorAndy N Mead
Jul 5, 2011·Neuroscience and Biobehavioral Reviews·Henri-Jean AubinGeorg Winterer
Mar 3, 2009·Journal of Psychopharmacology·K A BrennanP Truman
Mar 11, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bai-Fang X SobelRoland R Griffiths
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·June M StapletonEdythe D London
Jun 15, 2007·Journal of Health Communication·Michael Givel
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gary E SwanNeal L Benowitz

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