Subjective and Objective Measures of Daytime Activity and Sleep Disturbance in Retinitis Pigmentosa

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Ava K BittnerMichael T Smith

Abstract

Objectively measured limitations in daytime activity levels appear to be inextricably linked with sleep disturbances in retinitis pigmentosa (RP) patients, as well as associated with unemployment status and central vision loss. Innovative interventional strategies should be developed to help improve these issues and overall quality of life for RP patients. Novel sensor devices are emerging as valuable tools to objectively assess behavior. We used validated measures of wrist accelerometry to determine relationships between sleep, vision, and physical activity in RP subjects. For one week, 33 RP adults wore a wrist Actiwatch to detect movement during the day (average total activity counts) and disturbed sleep at night. They completed Early Treatment Diabetic Retinopathy Study visual acuity testing, Pelli-Robson contrast sensitivity, Goldmann V4e visual fields, and sleep diaries and validated questionnaires to assess their sleep and general health. Greater wake after sleep onset time measured with actigraphy (i.e., sleep disruption) (P = .01), loss of visual acuity (P = .009), and nonemployment/student status (P = .002) were all significant predictors of reduced daytime average total activity counts in a multiple linear regression...Continue Reading

References

May 15, 1988·American Journal of Ophthalmology·J R HeckenlivelyJ J Oversier
Oct 1, 1996·Optometry and Vision Science : Official Publication of the American Academy of Optometry·S HaymesA Johnston
Aug 14, 1998·Optometry and Vision Science : Official Publication of the American Academy of Optometry·D R GeruschatJ W Stahl
Sep 19, 2000·Medicine and Science in Sports and Exercise·A M SwartzB E Ainsworth
Jun 26, 2001·Journal of Sleep Research·M A GordoE J Sánchez-Barceló
Mar 21, 2002·Journal of Sleep Research·D IonescuC M Shapiro
Jun 19, 2002·Journal of Psychosomatic Research·Ania KorszunLeslie A Crofford
Sep 28, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Damien LegerMichel Paillard
Mar 18, 2003·Chronobiology International·Timothy H MonkDavid J Kupfer
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Jan 8, 2004·Diabetes Technology & Therapeutics·Kong Y ChenMaciej S Buchowski
Mar 17, 2004·Ophthalmology·Raymond Wee, Russell N Van Gelder
Apr 25, 2007·Ophthalmic Genetics·Dalbhir JangraAlex V Levin
Dec 19, 2008·Medicine and Science in Sports and Exercise·Suzanne HouwenChris Visscher
Jun 26, 2010·The British Journal of Ophthalmology·S A RivkeesM Borchert
Jun 10, 2011·Chest·Jennifer L Martin, Alex D Hakim
Oct 13, 2011·Medicine and Science in Sports and Exercise·Shaoyan ZhangTina L Hurst
Mar 6, 2012·Ophthalmology·Pradeep Y RamuluDavid S Friedman
Aug 16, 2012·Ophthalmology·Suzanne W van LandinghamPradeep Y Ramulu
Dec 19, 2012·Medicine and Science in Sports and Exercise·Mary E RosenbergerStephen Intille
Apr 19, 2013·Medicine and Science in Sports and Exercise·Patty S Freedson, Dinesh John
Jun 12, 2013·Mayo Clinic Proceedings·Paul D LoprinziPradeep Y Ramulu
Jun 27, 2014·Ophthalmic Epidemiology·Ah Reum AnBelong Cho
Aug 16, 2014·JAMA Ophthalmology·Paul D LoprinziPradeep Y Ramulu
Feb 1, 2015·BMC Ophthalmology·Sabyasachi SenguptaPradeep Y Ramulu
Aug 15, 2015·Behavioral Sleep Medicine·Michael T Smith
Aug 15, 2015·Behavioral Sleep Medicine·Sonia Ancoli-IsraelDaniel J Taylor
Nov 17, 2015·Investigative Ophthalmology & Visual Science·Adam M HanifMachelle T Pardue
Nov 21, 2015·Mini Reviews in Medicinal Chemistry·Joanna KrukHassan Y Aboul-Enein
Dec 30, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Keziah LathamShahina Pardhan
Jun 10, 2017·Journal of Ophthalmology·Joshua D LevinsonJiong Yan

❮ Previous
Next ❯

Citations

Sep 1, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Bradley Dougherty
Feb 12, 2021·Sleep Medicine Reviews·Sarah AtouiPaquito Bernard
Apr 4, 2021·Brain Sciences·Jessica HaytonDagmara Dimitriou
Jun 16, 2021·Orphanet Journal of Rare Diseases·Jeremy PomeroyRobert M Haws

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.