Subjective cognitive concern in multiple sclerosis is associated with reduced thalamic and cortical gray matter volumes

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Isaiah KletenikLuis D Medina

Abstract

Brain atrophy has been correlated with objective cognitive dysfunction in multiple sclerosis but few studies have explored self-reported subjective cognitive concerns and their relationship to brain volume changes. This study explores the relationship between subjective cognitive concerns in multiple sclerosis and reduced brain volume in regions of interest implicated in cognitive dysfunction. A total of 158 patients with multiple sclerosis completed the Quality of Life in Neurologic Disorders Measures (Neuro-QoL) short forms to assess subjective cognitive concerns and underwent brain magnetic resonance imaging. Regional brain volumes from regions of interest implicated in cognitive dysfunction were measured using NeuroQuant automated volumetric quantitation. Linear regression was used to analyze the relationship between subjective cognitive concerns and brain volume. Controlling for age, disease duration, gender, depression and fatigue, increased subjective cognitive concerns were associated with reduced thalamic volume (standardized β = 0.223, t150 =2.406, P = 0.017) and reduced cortical gray matter volume (standardized β = 0.240, t150 = 2.777, P = 0.006). Increased subjective cognitive concerns were not associated with any o...Continue Reading

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Citations

Apr 15, 2020·Annals of Neurology·Kedar R MahajanDaniel Ontaneda
Aug 28, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Grant L IversonDouglas P Terry
Oct 6, 2020·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Louis S MatzaDennis A Revicki

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Software Mentioned

Neuro
SIENAX
NeuroQuant
QoL
FIRST
SPSS

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