Subjective Cognitive Impairment and the Broad Autism Phenotype

Alzheimer Disease and Associated Disorders
Richard J CaselliBryan K Woodruff

Abstract

Roughly 4% to 23% of the population embody stress prone personality and other traits characterizing a subclinical "broad autism phenotype" (BAP). Subjective cognitive impairment (SCI) among healthy elderly is associated with psychological distress leading us to predict BAP would be associated with SCI. The Autism Spectrum Quotient, a self-administered 50 item questionnaire, was completed by 419 consecutive members of the Arizona APOE Cohort who underwent neuropsychological testing every 2 years. SCI was assessed with self and informant versions of the Multidimensional Assessment of Neurodegenerative Symptoms (MANS) Questionnaire. A total of 45 individuals scored in the BAP range, designated BAP+, and the rest were BAP-. At entry, both Multidimensional Assessment of Neurodegenerative Symptoms Questionnaire Self and Informant scores were higher in the BAP+ group (P<0.0001). After age 60, the BAP+ group had greater annual increases in Multidimensional Assessment of Neurodegenerative Symptoms Questionnaire Self scores (0.05 vs. 0.02; difference=0.03; 95% confidence interval, 0.004-0.05; P=0.02) yet there was no difference between groups in memory decline. Over ~10 years 33 individuals developed mild cognitive impairment: 4 in the B...Continue Reading

References

Sep 1, 1977·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Folstein, M Rutter
Oct 1, 1990·American Journal of Epidemiology·J H WareF E Speizer
Jul 1, 1994·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P BoltonM Rutter
Sep 1, 1993·Journal of Autism and Developmental Disorders·S OzonoffB F Pennington
Jan 1, 1997·Psychological Medicine·C HughesM Bouvard
Jul 25, 1997·American Journal of Medical Genetics·J PivenD Childress
Nov 30, 2000·Psychological Medicine·M MurphyM Rutter
May 23, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sven Bölte, Fritz Poustka
Nov 28, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·Richard DelormeMarion Leboyer
Dec 6, 2006·Journal of Autism and Developmental Disorders·Robert S E HurleyJoseph Piven
Oct 24, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Molly LoshJoseph Piven
May 6, 2009·Archives of General Psychiatry·Molly LoshJoseph Piven
May 4, 2011·Archives of General Psychiatry·Traolach S BrughaHoward Meltzer
Feb 22, 2013·Autism Research : Official Journal of the International Society for Autism Research·Noah J SassonJoseph Piven
Apr 2, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Richard J CaselliEric M Reiman
Apr 9, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Richard J CaselliEric M Reiman
Jul 1, 1997·Journal of Cognitive Neuroscience·S Baron-Cohen, J Hammer
Sep 24, 2013·Journal of Neurodevelopmental Disorders·Christina R MaxwellRobert T Schultz
Aug 26, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Rebecca L McLeanEric M Morrow
Mar 13, 2016·Autism Research : Official Journal of the International Society for Autism Research·Gregory L WallaceRebecca A Charlton
Aug 2, 2017·Autism Research and Treatment·Kavita RupareliaCharles R Newton
Sep 25, 2017·Autism Research : Official Journal of the International Society for Autism Research·B Blair BradenLeslie C Baxter

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

MANS
SAS
Informant

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.