PMID: 6405833Apr 1, 1983Paper

Subjective side-effects of amitriptyline and lithium in affective disorders

The British Journal of Psychiatry : the Journal of Mental Science
M Abou-Saleh, A Coppen

Abstract

The prevalence of subjective side-effects was studied in 258 control subjects, 65 drug-free depressive in-patients and 94 lithium-treated out-patients. It was shown that drug-free depressives reported more side-effects than both control subjects and lithium-treated patients. Side-effects were studied during amitriptyline therapy. Depressed patients on no medication complained of only slightly fewer side-effects than when they had received amitriptyline. There was a significant positive correlation of Hamilton depression scores and side-effects scores at baseline. Side-effects and affective morbidity over two years were investigated in 94 patients with recurrent affective disorders on long-term lithium therapy. Psychological variables were also investigated in 74 of these patients. Subjective side-effects reported by lithium-treated patients including those specific to lithium were related to their affective morbidity and personality variables. Patients on lithium complained significantly less of headache and unilateral headache than controls.

References

Jun 21, 1979·Psychopharmacology·A CoppenK Wood
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·A CoppenM Peet
Jan 1, 1975·The British Journal of Psychiatry : the Journal of Mental Science·M MetcalfeA Coppen
Jan 1, 1976·Acta Psychiatrica Scandinavica·P BechO J Rafaelsen
Feb 1, 1974·The American Journal of Psychiatry·R F PrienE M Caffey
Jun 1, 1970·The British Journal of Psychiatry : the Journal of Mental Science·M SchouJ Angst
Jun 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·R E Kendell, W J DiScipio
Sep 26, 1968·The New England Journal of Medicine·M M Reidenberg, D T Lowenthal
Mar 1, 1966·The British Journal of Medical Psychology·A Coppen
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Mar 1, 1965·The British Journal of Psychiatry : the Journal of Mental Science·A COPPEN, M METCALFE

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Citations

Jun 26, 2017·Current Psychiatry Reports·Peijun ChenMartha Sajatovic
Jan 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·R G McCreadie, D P Morrison
Sep 1, 1984·Canadian Anaesthetists' Society Journal·R J Marks
Jan 1, 1990·The Journal of Psychology·J B Murray
Jun 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·S Saxena, P Mallikarjuna
May 17, 2011·Psychiatry and Clinical Neurosciences·Basant K PradhanRahul Bhardwaj

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