PMID: 11320016Apr 26, 2001Paper

Subjective visual halos after sildenafil (Viagra) administration: Electroretinographic evaluation

Ophthalmology
C B GabrieliA Isidori

Abstract

The ophthalmologic and electroretinographic (ERG) findings in one subject with subjective visual disturbances after sildenafil administration are described. Interventional case report. A complete ophthalmologic examination was performed, including best-corrected visual acuity and ERG, repeated 1 and 2 hours after administration of 100 mg of sildenafil. Rod responses were obtained over a range of retinal illuminances from those producing a minimum detectable response to those producing rod saturation. Intensity amplitude function was determined. At 2 hours after 100 mg of oral sildenafil, we observed significant variations from baseline in parameters of best-fit Naka-Rushton function; V(max) was notably higher, and K was 0.14 log units lower than baseline. Sildenafil administration resulted in a higher rod response to light stimuli and in a higher rod sensitivity. These findings are consistent with the weak PDE-6 inhibition induced by sildenafil.

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Citations

Nov 5, 2002·Urology·Harin Padma-nathanFrancesco Montorsi
May 3, 2002·Ophthalmology·Michael J Potter, Darren Behn
Jun 25, 2003·Neurochemistry International·Péter BarabásJulianna Kardos
Sep 5, 2002·Progress in Retinal and Eye Research·Alan Laties, Eberhart Zrenner
Jun 19, 2003·The British Journal of Ophthalmology·J Shankar, S Kaye
Jun 19, 2003·The British Journal of Ophthalmology·J ShankarS Hanif
Feb 27, 2007·Optometry : Journal of the American Optometric Association·Joseph W SowkaLori A Vollmer
May 6, 2004·American Journal of Ophthalmology·Herbert JägleLindsay T Sharpe
Jul 25, 2009·Clinical & Experimental Ophthalmology·Nathan M Kerr, Helen V Danesh-Meyer
Jan 1, 2003·Human & Experimental Toxicology·A TracquiD Malicier
Feb 20, 2004·International Journal of Impotence Research·E KurtulanA A Esen
Nov 20, 2002·Expert Opinion on Pharmacotherapy·J S KalsiS Minhas
Dec 28, 2018·Spine Deformity·Morgane Le BerreJean-François Catanzariti
May 17, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Nabin R JoshiSuresh Viswanathan
Apr 1, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Mary A JohnsonAnthony G Robson
Apr 4, 2021·Biomedicines·Eva AusóGema Esquiva
Jun 28, 2021·Survey of Ophthalmology·Supriya AroraJay Chhablani

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