Subjects with congenital anosmia have larger peripheral but similar central trigeminal responses

Cerebral Cortex
Johannes FrasnelliThomas Hummel

Abstract

Most odorants not only stimulate olfactory receptor neurons but also activate the intranasal trigeminal nerve. The simultaneous activation of the olfactory and the trigeminal system leads to an interaction in the brain. Therefore, assessment of the trigeminal impact of odorants may be difficult in subjects with a normal sense of smell. To obtain a deeper insight into both, mechanisms of changes in trigeminal sensitivity in anosmic patients and interactions between the olfactory/trigeminal systems in healthy subjects, 21 patients with isolated congenital anosmia (ICA) were investigated in this series of explorative, hypothesis-generating experiments and compared with 35 healthy controls. Trigeminal sensitivity was measured by psychophysical (lateralization task, intensity ratings) and electrophysiological (trigeminal event-related potential, negative mucosal potential) means. ICA patients were found to have higher peripheral activation than controls. On central levels, however, similar responsiveness to trigeminal stimuli was found in ICA patients when compared with healthy subjects. The results of the study are discussed by proposing a model of mixed sensory adaptation/compensation in the interactions between olfactory and the ...Continue Reading

Citations

Jan 24, 2012·Chemical Senses·Johan N LundströmJohannes Frasnelli
Feb 2, 2012·Chemical Senses·Paul M WiseJohan N Lundström
Jan 9, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M BensafiT Hummel
Jan 28, 2015·Acta Oto-laryngologica·Valentin A Schriever, Thomas Hummel
Aug 1, 2014·Neuropsychologia·Léa GagnonMaurice Ptito
May 2, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Johanna L Reichert, Veronika Schöpf
Feb 20, 2015·Multisensory Research·Léa GagnonMaurice Ptito
Nov 15, 2007·American Journal of Rhinology·Philippe RombauxThomas Hummel
Oct 6, 2019·Journal of Neurology·Chloé Migneault-BouchardBasile Nicolas Landis
Sep 13, 2015·Developmental Neurobiology·Jacquelyn M OmelianSuzanne I Sollars
Jan 27, 2021·Cell and Tissue Research·Laura SchäferIlona Croy
Apr 10, 2021·Chemical Senses·Cécilia Tremblay, Johannes Frasnelli

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