Abstract
Most odorants not only stimulate olfactory receptor neurons but also activate the intranasal trigeminal nerve. The simultaneous activation of the olfactory and the trigeminal system leads to an interaction in the brain. Therefore, assessment of the trigeminal impact of odorants may be difficult in subjects with a normal sense of smell. To obtain a deeper insight into both, mechanisms of changes in trigeminal sensitivity in anosmic patients and interactions between the olfactory/trigeminal systems in healthy subjects, 21 patients with isolated congenital anosmia (ICA) were investigated in this series of explorative, hypothesis-generating experiments and compared with 35 healthy controls. Trigeminal sensitivity was measured by psychophysical (lateralization task, intensity ratings) and electrophysiological (trigeminal event-related potential, negative mucosal potential) means. ICA patients were found to have higher peripheral activation than controls. On central levels, however, similar responsiveness to trigeminal stimuli was found in ICA patients when compared with healthy subjects. The results of the study are discussed by proposing a model of mixed sensory adaptation/compensation in the interactions between olfactory and the ...Continue Reading
Citations
Jan 24, 2007·Chemical Senses·Didier TrotierCorinne Eloit
Jan 24, 2012·Chemical Senses·Johan N LundströmJohannes Frasnelli
Feb 2, 2012·Chemical Senses·Paul M WiseJohan N Lundström
Mar 20, 2012·PloS One·Caroline HuartAndré Mouraux
Jan 9, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M BensafiT Hummel
Jul 18, 2006·Neuroscience·J FrasnelliT Hummel
Jan 28, 2015·Acta Oto-laryngologica·Valentin A Schriever, Thomas Hummel
Nov 17, 2009·Brain Research Reviews·Jessica AlbrechtJohan N Lundström
Aug 1, 2014·Neuropsychologia·Léa GagnonMaurice Ptito
May 2, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Johanna L Reichert, Veronika Schöpf
Feb 20, 2015·Multisensory Research·Léa GagnonMaurice Ptito
Oct 4, 2017·Biology Open·Ed Zandro M TarocPaolo E Forni
Nov 15, 2007·American Journal of Rhinology·Philippe RombauxThomas Hummel
Apr 3, 2008·Human Brain Mapping·Jessica AlbrechtMartin Wiesmann
Mar 12, 2010·Journal of Neurology·Basile N LandisThomas Hummel
Jun 28, 2008·Pain·E IannilliT Hummel
Oct 6, 2019·Journal of Neurology·Chloé Migneault-BouchardBasile Nicolas Landis
Sep 2, 2020·Human Brain Mapping·Jörn LötschCarmen Walter
Sep 3, 2020·Scientific Reports·Akshita JoshiThomas Hummel
Sep 13, 2015·Developmental Neurobiology·Jacquelyn M OmelianSuzanne I Sollars
Jan 27, 2021·Cell and Tissue Research·Laura SchäferIlona Croy
Apr 10, 2021·Chemical Senses·Cécilia Tremblay, Johannes Frasnelli
Apr 25, 2021·Chemical Senses·David G LaingAnthony L Jinks
Oct 13, 2021·Rhinology·B-Y KimJ H Bae
Jun 3, 2020·NeuroImage·Moa G PeterJohan N Lundström