Sublay repair results in superior mesh incorporation and histological fibrogenesis in comparison to onlay and primary suture in an experimental rat model

Hernia : the Journal of Hernias and Abdominal Wall Surgery
F Ponce LeonR Martinez

Abstract

To compare adhesion scores, repair strength and histological findings among sublay, onlay and primary repair incisional hernioplasty techniques. Surgical repairs were employed directly on healthy animals, without previous hernia induction, to avoid confounding factors related to hernia development. Forty Wistar rats were divided into four groups, control, simulation, onlay and sublay. After 42 days, adhesion intensity, tensile strength of the abdominal wall and anatomopathological histological substrate were compared. SL group presented greater adhesion scores (p < 0.0001), higher tensiometric (p < 0.0001), and was characterized by more histiocytes, mononuclear cells, macrovacuolar granulomas and type I collagen on histological analysis. Pearson correlation between adhesions and tensiometry, and between tensiometry and neocollagenization showed a strong positive association (r = 0.8905 and 0.6757, respectively in SL group, p < 0.05). Mesh positioning in sublay compartment was followed by increased adhesion development and provides a stronger mesh-tissue attachment, in addition, resulted in a different histological profile of the inflammation/repair substrate. The intensity of these findings was directly correlated, suggesting t...Continue Reading

References

Mar 24, 1998·Journal of the American College of Surgeons·G J Morris-Stiff, L E Hughes
Aug 10, 2000·The New England Journal of Medicine·R W LuijendijkJ Jeekel
Jul 2, 2002·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J HöerV Schumpelick
Aug 3, 2002·The British Journal of Surgery·B KlosterhalfenU Klinge
Oct 10, 2003·The Surgical Clinics of North America·Keith W Millikan
Nov 6, 2009·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M BinneböselK Junge
Apr 28, 2010·Journal of the American College of Surgeons·Mary T HawnCatherine C Vick
May 14, 2010·Plastic and Reconstructive Surgery·Andrew M AltmanCharles E Butler
Aug 31, 2010·American Journal of Surgery·Fabrice SergentClaude Bunel
Aug 22, 2012·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A BaktirT Kuloglu
Dec 3, 2014·International Journal of Surgery·Melih AkinciOrhan Kozak
Jun 25, 2015·Acta Cirúrgica Brasileira·Edivaldo Massazo UtiyamaEdna Frasson de Souza Montero
Oct 2, 2015·World Journal of Surgery·Julie L HolihanMike K Liang
Nov 6, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Leonardo Carvalho SerigiollePedro Luiz Squilacci Leme
Dec 2, 2015·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A SchachtruppJ Höer
Jun 9, 2016·Acta Cirúrgica Brasileira·Maria de Lourdes Pessole Biondo-SimõesFlávio Daniel Saavedra Tomasich
Jun 24, 2016·Hernia : the Journal of Hernias and Abdominal Wall Surgery·C T MaedaM M Linhares
Oct 12, 2017·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Carlos Alberto Lima UtraboOsvaldo Malafaia

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Citations

Jan 13, 2021·Hernia : the Journal of Hernias and Abdominal Wall Surgery·T Whitehead-ClarkeA Kureshi

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