Sublethal concentrations of triclosan elicited oxidative stress, DNA damage, and histological alterations in the liver and brain of adult zebrafish

Environmental Science and Pollution Research International
Eric GyimahHai Xu

Abstract

Triclosan (TCS), an antimicrobial agent, has been a pollutant of increasing concern owing to its potential health risk on humans and aquatic animals. The present study seeks to test the hypothesis that TCS could alter the oxidative stress-related parameters in the brain and liver, as well as eliciting DNA damage in hepatocytes of adult zebrafish. On the basis of the 96 h LC50 (398.9 μg/L), adult zebrafish were separately exposed to 50, 100, and 150 μg/L TCS for 30 days. The brain and liver tissues from adult zebrafish were excised and assayed for a suite of antioxidant parameters and oxidative stress biomarkers including DNA damage in the liver. The induced effect by TCS on the activity of acetylcholinesterase (AChE) was also analyzed in the brain. Results showed a significant decrease in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the brain and liver of adult zebrafish. Also, the contents of the glutathione system (GSH and GSSH), as well as the activity of the glutathione reductase (GR), assayed in the liver, were reduced while the contents of malondialdehyde (MDA) were elevated in the liver. A comet assay revealed dose-dependent DNA damage in zebrafish hepatocytes. The 8-hydroxy-2'-deoxygua...Continue Reading

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Citations

Jan 6, 2021·Animals : an Open Access Journal From MDPI·Maryna van de VenterLuanne Venables
Dec 8, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mine KöktürkMehmet Salih Nas
Jul 14, 2021·Environmental Science and Pollution Research International·Sunil SharmaArvinder Kaur
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying HanYuxuan Liu
Oct 8, 2021·The Science of the Total Environment·Rong ZhongJianbo Tian

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