Sublethal effects in Atlantic salmon (Salmo salar) exposed to mixtures of copper, aluminium and gamma radiation

Journal of Environmental Radioactivity
Lene Sørlie HeierBrit Salbu

Abstract

The present study was designed to investigate the effects in presmolt of Atlantic salmon (Salmo salar) exposed to copper (Cu), aluminium (Al) and gamma radiation, individually or in combination. Fish were exposed for 48 h to metals added to lake water; 10, 40 and 80 μg Cu/L, 250 μg Al/L and a combination of 40 μg Cu/L and 250 μg Al/L. In addition, gamma radiation (4-70 mGy delivered over 48 h) was added as an additional exposure stressor. Selected endpoints were chosen to reveal different toxic mechanisms and included Cu and Al accumulation on gills, blood chemistry and haematological variables (plasma sodium and chloride, haematocrit, glucose), hepatic levels of reduced and oxidised glutathione (GSH and GSSG) and hepatic transcriptional response of glutathione peroxidase (GPx), gamma-glutamylcysteine synthetase (GCS), metallothionein (MT) and ubiquitin. Exposure to Cu alone resulted in gill accumulation of Cu, reduction of plasma ions and increased transcriptional response of GPx, MT and ubiquitin. Exposure to Al alone reduced plasma ion levels but did not affect any of the hepatic biomarkers except for ubiquitin. The combined metal exposure (Cu + Al) altered the GSH levels, however GPx and MT were not affected suggesting a di...Continue Reading

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Citations

Mar 5, 2016·Journal of Radiation Research·Candy Y P NgKwan Ngok Yu
Apr 26, 2020·International Journal of Environmental Research and Public Health·W S KwanK N Yu
Apr 12, 2019·International Journal of Radiation Biology·B SalbuK E Tollefsen
Sep 25, 2020·International Journal of Radiation Biology·Emily L VernonAwadhesh N Jha

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