Sublingual administration of captopril in patients with acute myocardial ischemia

Clinical Cardiology
M HaudeJ Meyer


To investigate the anti-ischemic capability of the angiotensin-converting enzyme inhibitor captopril, 10 patients with acute myocardial ischemia (angina pectoris less than 1 h, ST-segment depression greater than or equal to 0.1 mV, no rise in creatine phosphokinase) received 25 mg captopril sublingually after being treated with an intravenous infusion of nitroglycerin (3 mg/h) and heparin (1200 IU/h) for 1 hour. A control group of 10 patients received placebo instead of captopril. Results showed a decrease of the initial ST-segment depression from 0.25 +/- 0.04 to 0.2 +/- 0.03 mV (p less than 0.01) with nitroglycerin for the captopril group and from 0.26 +/- 0.05 to 0.21 +/- 0.05 mV (p less than 0.01) for the control group. An additional decrease to 0.13 +/- 0.03 mV (p less than 0.001) was measured after sublingual captopril, while no significant change was found in the placebo group (0.19 +/- 0.04 mV). In both groups, 3 patients had no incidents of angina after 1-h nitroglycerin infusion. An additional 6 patients resolved their complaints after captopril administration in contrast to only 1 after placebo. Two patients in the placebo group required increased doses of nitroglycerin because of impairment of anginal complaints. He...Continue Reading


Aug 4, 1977·The New England Journal of Medicine·J N Cohn, J A Franciosa
Jan 1, 1977·Progress in Cardiovascular Diseases·K Chatterjee, W Parmley
Jul 7, 1977·The New England Journal of Medicine·J N Cohn, J A Franciosa
Jul 14, 1989·Deutsche medizinische Wochenschrift·M HaudeJ Meyer
Jan 25, 1986·Lancet·J H Hauger-Klevene
Jul 1, 1987·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·K LindpaintnerD Ganten
Dec 1, 1987·Kidney International·J J BeukersJ J Weening
Mar 26, 1985·European Journal of Pharmacology·K NoguchiM Sakanashi
Sep 1, 1974·Progress in Cardiovascular Diseases·H R BrunnerJ H Laragh
May 31, 1984·The American Journal of Medicine·P DalyJ H Burgess


Dec 16, 1998·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·K GemiciN Çobanoglu

Related Concepts

Acute Disease
Angina Pectoris
Clinical Trials
Coronary Heart Disease
Macro-Creatine Kinase
Electrocardiographic Recorders

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.