Sublingual administration of liposomes enclosing alpha-galactosylceramide as an effective adjuvant of allergen immunotherapy in a murine model of allergic rhinitis

Allergology International : Official Journal of the Japanese Society of Allergology
Satoshi SuzukiY Okamoto

Abstract

Sublingual immunotherapy (SLIT) is an established efficacious approach for the treatment of allergic rhinitis (AR). However, SLIT requires a long administration period to establish stable and adequate responses. This study investigated the efficacy of the sublingual administration of an allergen with liposomes enclosing α-GalCer (α-GC-liposome) as a potential adjuvant in mice with AR. Mice with AR induced by OVA received the sublingual administration of OVA, α-GC-liposomes, or OVA plus α-GC-liposomes for 7 days. After nasal re-challenge with OVA, nasal symptoms were evaluated. The serum levels of OVA-specific Ig, the cytokine production of CD4+ T cells in the cultures of cervical lymph node (CLN) cells, and the gene expression of CLNs were analyzed. Although IL-4, IL-5 and IL-13 production from CD4+ T cells in CLN cells was significantly inhibited by the sublingual administration of OVA alone in mice with AR induced by OVA, their nasal symptoms were not significantly diminished. However, the combined sublingual administration of α-GC-liposomes and OVA completely suppressed nasal symptoms, downregulated Th2 and Th17 type cytokine production in CD4+ T cells as well as Th2 and Th17 gene expressions, and upregulated Th1 type cytoki...Continue Reading

Citations

Dec 5, 2019·European Journal of Immunology·Bernhard KratzerWinfried F Pickl
Feb 5, 2021·Advanced Drug Delivery Reviews·S G AntimisiarisS Mourtas
Feb 20, 2021·Molecular Pharmaceutics·Brianna CoteAdam W G Alani
Sep 4, 2020·Chemistry and Physics of Lipids·Letícia S MartinsJulio H K Rozenfeld

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