Sublingual administration of tacrolimus in a renal transplant patient

Journal of Clinical Pharmacy and Therapeutics
I RomeroA Carcas

Abstract

Tacrolimus is used in renal and other organ transplantations for immunossupression therapy. Bioavailability of enterally administered tacrolimus is poor, and further reduced by gastrointestinal failure or enteral nutrition. In these situations, intravenous administration is necessary to prevent treatment failure. However, intravenous administration should be done in a continuous manner and it has been implicated in anaphylaxis, torsades de pointes, cardiac arrhythmia and other serious adverse events. Also it is more expensive than other routes of administration. Sublingual administration of tacrolimus has been used in some cases, and literature reports show that it provides therapeutic tacrolimus levels in lung and liver transplant recipients. Here, we report a first case of sublingual administration of tacrolimus in kidney transplantation.

References

Dec 1, 1995·Clinical Pharmacokinetics·R VenkataramananT Starzl
Mar 16, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D ReamsS Palmer
Apr 16, 2002·Clinical Therapeutics·Barry D KahanAtholl Johnston
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·B Diane Reams, Scott M Palmer
Jul 13, 2004·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Jul 26, 2005·Drugs & Aging·Christine E Staatz, Susan E Tett
Feb 28, 2006·Pediatric Transplantation·Joanne F GoorhuisMarcel J I J Albers

❮ Previous
Next ❯

Citations

Jul 10, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Zahra Nasiri-ToosiSima Sadrai
Sep 18, 2008·Drug Development and Industrial Pharmacy·Alan B WattsJay I Peters
Oct 4, 2011·Drug Development and Industrial Pharmacy·Parinda SrinarongHenderik W Frijlink
Dec 20, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Katherine D WatkinsJonathan P Singer
Nov 5, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Afke van de PlasCees Neef
Jan 12, 2013·Pharmacotherapy·Demetra TsapepasMeredith Aull
Sep 25, 2014·Pharmacotherapy·Christina Teeter DoligalskiAngela Tong Logan
May 9, 2014·British Journal of Clinical Pharmacology·Frank StifftMaarten Christiaans
Jan 30, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Catherine A Pennington, Jeong M Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

© 2021 Meta ULC. All rights reserved