Sublingual allergoid immunotherapy: a new 4-day induction phase in patients allergic to house dust mites

International Journal of Immunopathology and Pharmacology
R D'AnneoP Falagiani

Abstract

Sublingual immunotherapy with monomeric allergoid (allergoid SLIT), given according to the standard scheme, has proved effective and safe in many clinical trials. However, its build-up phase requires a long time ranging from 16 days to 14 weeks. This study therefore investigated whether, with a four-day up-dosing, the same benefit could be achieved in a shorter time. Thirty rhinitic and/or asthmatic patients (16 M and 14 F, mean age 36+/-8.2 years) allergic to house dust mites (HDM) with or without other sensitizations were randomized to allergoid SLIT or standard drug therapy. The build-up phase lasted four days. The first day the patients took a 300 AU tablet, the second day two 300 AU tablets, the third day three 300 AU tablets and the fourth day four 300 AU tablets. The total amount taken during the up-dosing was 3000 AU. Patients were then treated for 12 months at the dosage of 2000 AU/week (total amount of allergen: 104,000 AU/year). The symptom score and drug consumption were recorded from November to February on monthly diary cards. At baseline and after 12 months a Visual Analogue Scale (VAS) was used to rate the patients? well-being. Skin prick test reactivity was evaluated before and after the 12-month treatment in b...Continue Reading

References

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Apr 17, 2009·The Journal of Allergy and Clinical Immunology·Philippe-Jean BousquetJean Bousquet

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Citations

Dec 22, 2011·Clinical Reviews in Allergy & Immunology·Christopher Chang
Feb 11, 2016·Immunotherapy·Nhung T NguyenRalph Mösges
Sep 15, 2020·The Cochrane Database of Systematic Reviews·Rebecca FortescueMarco Shiu Tsun Leung
Sep 1, 2015·The Cochrane Database of Systematic Reviews·Rebecca NormansellAmy-Louise Bridgman

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