PMID: 16509417Mar 3, 2006Paper

Sublingual immunotherapy--coming of age?

Harefuah
Mona Iancovici Kidon, D Nelken

Abstract

Immunotherapy is the only therapeutic modality in allergic patients with long lasting effects on the reactivity of the immune system to specific allergen exposure. Classical, subcutaneous, immunotherapy is associated with ubiquitous local and rare but potentially life-threatening systemic side effects. Sublingual immunotherapy is a relatively new modality of treatment, utilizing daily gradually increasing concentrations of allergen that are placed sublingually for a few minutes and swallowed afterwards. To summarize "state of the art" concepts on sublingual immunotherapy, its mechanisms of action as well as safety and efficacy in the treatment of allergic disease. A Medline search was performed through the PubMed service of the National Library of Medicine, for the period 1985 to December 2004, using "sublingual" and "imm unotherapy" in the title or abstract. The latest Cochrane Library meta-analysis on the subject was extracted as well as the original publications on which the analysis is based. Sublingual immunotherapy is a safe treatment in patients of all ages with asthma and other allergic diseases. The modality is more effective than placebo in the treatment of allergic rhinitis in adults. Our local experience supports a ...Continue Reading

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