Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Johanna HuomanMaria C Jenmalm

Abstract

Immunomodulatory effects of sublingual immunotherapy on systemic and mucosal mediators in allergic children are largely unexplored. The aim of this study was to investigate allergy-related cytokine and chemokine levels, as well as IgA-responses upon a 3-year treatment with timothy grass pollen sublingual immunotherapy in children with allergic rhinoconjunctivitis. From children included in the GRAZAX® Asthma Prevention study, blood and saliva samples were analyzed at inclusion, after 3 years of treatment, and 2 years after treatment ending. By means of Luminex and ELISA methodologies, allergy-related cytokines and chemokines were measured in plasma samples and allergen-stimulated peripheral blood mononuclear cell supernatants. Furthermore, studies of total, secretory, and Phl p 1-specific salivary IgA antibodies were performed using the same methods. GRAZAX® -treated children exhibited significantly higher levels of Phl p 1-specific salivary IgA and serum IgG4 , along with significantly lower skin prick test positivity, after 3 years of treatment and 2 years after treatment cessation. Additionally, plasma levels of the Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in treated than untreated children at th...Continue Reading

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Citations

Jun 12, 2020·Children·Michele Miraglia Del GiudiceGiorgio Ciprandi
Dec 15, 2020·Current Allergy and Asthma Reports·Gabija DrazdauskaitėMohamed H Shamji

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