Sublingual immunotherapy for pediatric allergic conjunctivitis: a meta-analysis of randomized controlled trials

International Forum of Allergy & Rhinology
Jie YangShiyu Liao

Abstract

Allergic conjunctivitis (AC) is a common chronic condition, especially in children. Ocular symptoms are often overlooked during treatment of allergic rhinoconjunctivitis (ARC). Pediatric ARC can be effectively treated using sublingual immunotherapy (SLIT), which is a guideline-recommended safe treatment approach. However, the therapeutic efficacy of SLIT in terms of ameliorating eye symptoms has not been effectively evaluated. We performed a meta-analysis of randomized controlled trials (RCTs) evaluating the use of SLIT for infants, children, and adolescents (aged from 3 to 18 years) with AC or ARC. We searched the Cochrane Library database, EMBASE, and Medline from November 1990 to 2017 to find papers dealing with the effects of SLIT on pediatric AC or ARC. We used standardized mean differences (SMDs) to assess therapeutic effects, employing a random effects model. Subgroup and sensitivity analyses were also conducted. The I2 metric was used to evaluate heterogeneity. In total, 13 clinical RCTs were included in our meta-analysis. SLIT reduced ocular symptoms to a level below that of controls (SMD = -0.21; 95% confidence interval [CI], -0.41 to -0.01; p = 0.04; I2 = 55%). Notably, on subgroup analysis, SLIT clearly reduced poll...Continue Reading

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Citations

Oct 30, 2018·International Forum of Allergy & Rhinology·Luo Zhang
Jun 20, 2020·Current Opinion in Allergy and Clinical Immunology·Nofar Kimchi, Leonard Bielory
Aug 3, 2020·Current Opinion in Allergy and Clinical Immunology·Jayesh VaziraniSayan Basu
Apr 25, 2020·International Forum of Allergy & Rhinology·Liang ChenTianlin Li
Sep 19, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Amruta Trivedi, Constance Katelaris
Jan 30, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Pascale DupuisHarold Kim

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