Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period

The Journal of Laryngology and Otology
J Y SohS S Chao

Abstract

Sublingual immunotherapy in patients with allergic rhinitis sensitised to house dust mites is safe, but its efficacy is controversial and sublingual immunotherapy with Blomia tropicalis has not yet been studied. This study sought to evaluate the efficacy of sublingual immunotherapy with house dust mite extract in children and adults with house dust mite allergic rhinitis over a period of two years. A prospective observational study was conducted of children and adults diagnosed with house dust mite allergic rhinitis who were treated with sublingual immunotherapy from 2008 to 2012. Total Nasal Symptom Scores, Mini Rhinoconjunctivitis Quality of Life scores and medication usage scores were assessed prospectively. Thirty-nine patients, comprising 24 children and 15 adults, were studied. Total Nasal Symptom Scores and Mini Rhinoconjunctivitis Quality of Life scores dropped significantly at three months into therapy, and continued to improve. Medication usage scores improved at one year into immunotherapy. Sublingual immunotherapy with house dust mite extracts, including B tropicalis, is efficacious as a treatment for patients with house dust mite allergic rhinitis.

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Citations

Nov 18, 2017·The Journal of Laryngology and Otology·Jonathan FishmanMusheer Hussain
May 11, 2017·Asia Pacific Allergy·Bernard Yu-Hor Thong
Jan 1, 2021·Annals of the Academy of Medicine, Singapore·Xuandao LiuJean Bousquet
May 15, 2021·International Journal of Immunopathology and Pharmacology·Matheus Fonseca AarestrupFernando Monteiro Aarestrup

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