Sublingual Immunotherapy with a Five-Grass Pollen Tablet in Adult Patients with Allergic Rhinitis: An Open, Prospective, Noninterventional, Multicenter Study

BioMed Research International
Oliver PfaarEfstrathios Karagiannis

Abstract

Although the safety and efficacy of sublingual immunotherapy (SLIT) with a five-grass pollen tablet have been demonstrated in randomized clinical trials (RCTs), these outcomes must always be evaluated in real-life medical practice. In a prospective, open-label, noninterventional, "real-life" study in Germany, we evaluated the safety, tolerability, and effectiveness of SLIT with a five-grass pollen tablet in adults with grass-pollen-induced allergic rhinoconjunctivitis. 808 adults were enrolled between September 2008 and December 2009. 35.3% of the participants experienced at least one adverse drug reaction (ADR), the most common of which were mild-to-moderate gastrointestinal and respiratory disorders. Serious ADRs considered causally related to SLIT treatment occurred in four patients. Overall, the five-grass pollen tablet was considered to have good or very good tolerability by most investigators and patients. Treatment was associated with the relief of nasal, ocular, and bronchial symptoms and decreased symptomatic medication use. However, interpretation of clinical improvements was limited by lower atmospheric grass pollen levels during the study season (relative to the preceding season). In a large population of patients t...Continue Reading

References

Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R F LockeyS C Bukantz
Mar 26, 2008·International Archives of Allergy and Immunology·Philippe MoingeonGabriel Peltre
Dec 3, 2008·The Journal of Allergy and Clinical Immunology·Ulrich WahnUNKNOWN SLIT Study Group
Jan 13, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H-J MallingA Didier
Feb 6, 2010·Allergy·G Walter CanonicaStefan Vieths
Feb 20, 2010·American Journal of Rhinology & Allergy·Oliver PfaarMatthias Bräutigam
Aug 20, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Susanne HalkenUlrich Wahn
Oct 23, 2010·The Journal of Allergy and Clinical Immunology·Moisés A CalderónPascal Demoly
Dec 3, 2010·The Journal of Allergy and Clinical Immunology·Linda CoxDana Wallace
Jan 29, 2011·The Journal of Allergy and Clinical Immunology·David J CostaUNKNOWN Languedoc-Roussillon Teaching General Practitioners Group
Nov 6, 2012·The Journal of Allergy and Clinical Immunology·Linda S CoxRobert K Zeldin
Dec 22, 2012·Immunotherapy·Juliane Köberlein, Ralph Mösges
Mar 1, 2013·Immunotherapy·Giovanni PassalacquaGiorgio Walter Canonica

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Citations

Mar 8, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe DevillierOlivier de Beaumont
Jun 6, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Maria Lucía Orsini DelgadoGuillermo Horacio Docena
Jun 9, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Lubnaa HossenbaccusAnne K Ellis
Apr 30, 2017·Advances in Therapy·Kija Shah-HosseiniRalph Mösges

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