PMID: 8971284Dec 1, 1996Paper

Sublingual nitroglycerine: effects on contractile activity of the distal oesophagus and lower oesophageal sphincter in healthy men

Alimentary Pharmacology & Therapeutics
Georg StacherU Weber

Abstract

Nitric oxide plays an important role in the control of gastrointestinal motility. This study assessed the effects of graded doses of the nitric oxide-releasing agent, nitroglycerine, on distal oesophageal motor activity and lower oesophageal sphincter resting pressure. Eight healthy young men received at 1-week intervals placebo, 0.2 mg, 0.4 mg or 0.8 mg nitroglycerine sublingually under random double-blind conditions. Sphincter pressure was recorded using a Dent sleeve and oesophageal motility using sensors 1, 4, 7 and 10 cm orad the sleeve during two 15-min periods before and four 15-min periods after drug administration. In minutes 4 to 6 of each period, subjects swallowed 5 mL water at 30 s intervals. After 0.2 mg and 0.4 mg nitroglycerine, amplitude, duration and area under curve of swallow-initiated contractions were smaller than after placebo. After 0.8 mg nitroglycerine, amplitude, duration and area under curve were slightly greater than after placebo and significantly greater than after the lower nitroglycerine doses. No effects were discernible on onset latency and propagation velocity of contractions as well as on lower oesophageal sphincter resting pressure. Sublingual nitroglycerine had modest, dose-dependent effec...Continue Reading

Citations

Sep 25, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eneysis M PenaSudarshan R Jadcherla
Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X ZhangD A Sifrim
Jul 8, 2005·The Journal of Cardiovascular Nursing·Juanita Reigle
Feb 22, 2012·Scandinavian Journal of Gastroenterology·John P SeenanKenneth E L McColl

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