Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jing ZhangY Wang

Abstract

CCAAT/enhancer-binding protein (C/EBPβ)-enhanced IL-6 and TGF-β1 promoter activity and p300-mediated C/EBPβ acetylation were involved in up-regulation of IL-6 and TGF-β1 expression in GMCs attacked by sublytic C5b-9. In detail, the elements of C/EBPβ binding to rat IL-6 and TGF-β1 promoter and 3 acetylated sites of rat C/EBPβ protein were first revealed. Furthermore, silencing the p300 or C/EBPβ gene in rat kidney significantly reduced the production of IL-6 and TGF-β1 and renal lesions in Thy-1N rats. Together, these data indicate that the mechanism of IL-6 and TGF-β1 production in renal tissue of Thy-1N rats is associated with sublytic C5b-9 up-regulated p300 and p300-mediated C/EBPβ acetylation as well as C/EBPβ-activated IL-6 and TGF-β1 genes.

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Citations

May 6, 2016·Frontiers in Immunology·Barbora KnoppovaJan Novak
Jan 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ganqian ZhuYingwei Wang
Nov 9, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing ZhangYingwei Wang
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May 10, 2017·Frontiers in Immunology·Hua SuChun Zhang
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Aug 12, 2021·Seminars in Immunopathology·Nicholas R Medjeral-ThomasMatthew C Pickering
Sep 18, 2021·Clinical Science·Erika I Boesen, Rahul M Kakalij

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