PMID: 9663436Jul 15, 1998Paper

Submandibular salivary proteases: lack of a role in anti-HIV activity

Journal of Dental Research
S KennedyD Malamud

Abstract

Whole human saliva contains a number of proteolytic enzymes, mostly derived from white blood cells and bacteria in the oral cavity. However, less information is available regarding proteases produced by salivary glands and present in salivary secretions. In the present study, we have analyzed submandibular saliva, collected without contaminating cells, and identified multiple proteolytic activities. These have been characterized in terms of their susceptibility to a series of protease inhibitors. The submandibular saliva proteases were shown to be sensitive to both serine and acidic protease inhibitors. We also used protease inhibitors to determine if salivary proteolytic activity was involved in the inhibition of HIV infectivity seen when the virus is incubated with human saliva. This anti-HIV activity has been reported to occur in whole saliva and in ductal saliva obtained from both the parotid and submandibular glands, with highest levels of activity present in the latter fluid. Protease inhibitors, at concentrations sufficient to block salivary proteolytic activity in an in vitro infectivity assay, did not block the anti-HIV effects of saliva, suggesting that the salivary proteases are not responsible for the inhibition of ...Continue Reading

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Citations

Aug 8, 2002·Oral Diseases·D C ShugarsS J Challacombe
May 1, 1997·Oral Diseases·D MalamudH M Friedman
Oct 27, 2010·Expert Review of Proteomics·Francisco AmadoRui Vitorino
Jan 12, 2010·Medical Hypotheses·Gururaj Arakeri
Aug 19, 2007·Archives of Oral Biology·Raymond G SchipperMonique H Vingerhoeds
Oct 30, 2015·European Journal of Oral Sciences·Guus van StrijpYouichi Iijima
Jul 13, 1999·Archives of Oral Biology·D C ShugarsS A Freel
Oct 31, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Raymond SchipperWaander van Heerde
Mar 7, 2000·Oral Diseases·C Scully, S Porter
Sep 10, 2020·Pathogens·Kaitlin McBrideAntonieta Guerrero-Plata
Jan 18, 2006·Analytical Chemistry·John R YatesVlad Zabrouskov

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