Submaximal exercise testing using lactate threshold and venous oxygen tension as endpoints in normal dogs and in dogs with heart failure

Journal of Veterinary Internal Medicine
M D KittlesonP D Pion

Abstract

Twelve normal dogs and 7 dogs with experimentally induced heart failure were chronically instrumented to measure hemodynamic variables and blood gas tensions at rest and during graded treadmill exercise. Three groups of 4 normal dogs each (group 1, 15 to 20 kg; group 2, 21 to 30 kg; group 3, 31 to 40 kg) were exercised on a treadmill at a 16% grade at 1, 2, and 3 miles per hour, and at a 22% and a 26% grade at 3 miles per hour (5 total exercise levels) until blood lactate concentration increased to a value greater than 1 mmol/L. Blood lactate concentration and blood gas tensions were measured 5 and 15 minutes after starting exercise, and cardiac output was measured between 8 and 10 minutes of exercise. Results indicated that the same exercise protocol could be used for dogs ranging in size from 15 to 40 kg. Blood lactate concentration increased in normal dogs at varying workloads, but always at or above a workload of 3 miles per hour at a 16% grade. Dogs with class IV heart failure always experienced an increase in blood lactate concentration when walked at 1 mile per hour at a 16% grade for 5 minutes. A femoral vein PO2 between 21 and 24 mm Hg in normal dogs, and between 16 and 22 mm Hg in dogs with heart failure was always as...Continue Reading

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Citations

May 21, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Luca Ferasin, Samuele Marcora
Nov 28, 2013·Regulatory Toxicology and Pharmacology : RTP·Dennis J Murphy
May 21, 2014·Journal of Pharmacological and Toxicological Methods·Dennis J Murphy
Mar 19, 2004·American Journal of Veterinary Research·Kirstin N BoddyRobert L Hamlin
Mar 7, 2020·The Journal of Sports Medicine and Physical Fitness·João C AlvesPilar Lafuente
Feb 26, 2019·American Journal of Veterinary Research·Alejandro Z RestanGuilherme C Ferraz
Oct 9, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Marcondes-SantosC M C Strunz

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