Submicron-surface structured tricalcium phosphate ceramic enhances the bone regeneration in canine spine environment

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Rongquan DuanHuipin Yuan

Abstract

Calcium phosphate ceramics with submicron-scaled surface structure can trigger bone formation in non-osseous sites and are expected to enhance bone formation in spine environment. In this study, two tricalcium phosphate ceramics having either a submicron-scaled surface structure (TCP-S) or a micron-scaled one (TCP-B) were prepared and characterized regarding their physicochemical properties. Granules (size 1-2 mm) of both materials were implanted on either left or right side of spinous process, between the two lumbar vertebrae (L3-L4), and in paraspinal muscle of eight beagles. After 12 weeks of implantation, ectopic bone was observed in muscle in TCP-S explants (7.7 ± 3.7%), confirming their ability to inductively form bone in non-osseous sites. In contrast, TCP-B implants did not lead to bone formation in muscle. Abundant bone (34.1 ± 6.6%) was formed within TCP-S implants beside the two spinous processes, while limited bone (5.1 ± 4.5%) was seen in TCP-B. Furthermore, the material resorption of TCP-S was more pronounced than that of TCP-B in both the muscle and spine environments. The results herein indicate that the submicron-scaled surface structured tricalcium phosphate ceramic could enhance bone regeneration as compared ...Continue Reading

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Citations

Jan 8, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lukas A van DijkJoost D de Bruijn
Jan 25, 2020·Clinical Spine Surgery : a Spine Publication·Lukas A van DijkWilliam R Walsh
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rongquan DuanJoost de Bruijn
May 26, 2021·The Spine Journal : Official Journal of the North American Spine Society·Jordan C ConwayIain R Gibson
Sep 18, 2018·ACS Biomaterials Science & Engineering·Rongquan DuanHuipin Yuan

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