PMID: 9539799May 16, 1998Paper

Submicrosecond pacemaker precision is behaviorally modulated: the gymnotiform electromotor pathway

Proceedings of the National Academy of Sciences of the United States of America
K T MoortgatT J Sejnowski

Abstract

What are the limits and modulators of neural precision? We address this question in the most regular biological oscillator known, the electric organ command nucleus in the brainstem of wave-type gymnotiform fish. These fish produce an oscillating electric field, the electric organ discharge (EOD), used in electrolocation and communication. We show here that the EOD precision, measured by the coefficient of variation (CV = SD/mean period) is as low as 2 x 10(-4) in five species representing three families that range widely in species and individual mean EOD frequencies (70-1,250 Hz). Intracellular recording in the pacemaker nucleus (Pn), which commands the EOD cycle by cycle, revealed that individual Pn neurons of the same species also display an extremely low CV (CV = 6 x 10(-4), 0.8 micro sec SD). Although the EOD CV can remain at its minimum for hours, it varies with novel environmental conditions, during communication, and spontaneously. Spontaneous changes occur as abrupt steps (250 ms), oscillations (3-5 Hz), or slow ramps (10-30 s). Several findings suggest that these changes are under active control and depend on behavioral state: mean EOD frequency and CV can change independently; CV often decreases in response to behav...Continue Reading

References

Jul 1, 1978·IEEE Transactions on Bio-medical Engineering·D E GustafsonJ H Triebwasser
May 1, 1976·Scientific American·J Buck, E Buck
Feb 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·T T Takahashi, C H Keller
Oct 1, 1991·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·C H KellerW Heiligenberg
Oct 1, 1989·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·M Kawasaki, W Heiligenberg
Aug 1, 1987·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J Dye, W Heiligenberg
May 1, 1970·The Journal of General Physiology·T H Bullock
Nov 1, 1968·Comparative Biochemistry and Physiology·P S Enger, T Szabo
Jun 9, 1995·Science·Z F Mainen, T J Sejnowski
Aug 1, 1993·Journal of Applied Physiology·M SammonE N Bruce
Jan 1, 1993·Annual Review of Neuroscience·C E Carr
Nov 1, 1996·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·W HeiligenbergC H Keller
Mar 21, 1997·Science·R R de Ruyter van SteveninckW Bialek
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·M J BerryM Meister
Aug 1, 1997·Current Opinion in Neurobiology·M Kawasaki
Sep 1, 1954·The Japanese Journal of Physiology·S HAGIWARA
Oct 29, 1956·The Journal of Physiology·T H BULLOCK, F P DIECKE

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Citations

Oct 26, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·G K H ZupancI Ilies
Apr 29, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·M E Nelson, M A MacIver
Nov 6, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Laura QuintanaOmar Macadar
Feb 3, 2005·Biological cybernetics·Leonel GómezJosé Pedro Segundo
Jun 24, 2004·Bulletin of Mathematical Biology·Alberto Capurro, C P Malta
Dec 10, 2003·Current Opinion in Neurobiology·Harold H Zakon
Dec 25, 2003·Journal of Physiology, Paris·Harold ZakonFrank Triefenbach
Mar 29, 2000·Network : Computation in Neural Systems·P H Tiesinga, J V José
Sep 30, 2000·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·A DraguhnD Schmitz
Oct 29, 2010·Biology Letters·Vincent FugèreRüdiger Krahe
Feb 26, 2010·Journal of Neurophysiology·Nikolai C DembrowHarold H Zakon
Jun 25, 2002·Neural Computation·Relly Brandman, Mark E Nelson
Jul 19, 2012·PLoS Computational Biology·Na YuAndré Longtin
Sep 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jason W MiddletonLeonard Maler
Nov 11, 2008·Journal of Physiology, Paris·Mark E Nelson
Jun 27, 2006·Journal of Neuroscience Methods·David K Chelvanayagam, Trichur R Vidyasagar
Feb 9, 2007·Journal of Neurophysiology·Daniel GussinLeonard Maler
Apr 2, 2010·Journal of Neurophysiology·Reza KhanbabaieLeonard Maler
Oct 24, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·G Troy SmithDouglas B Rusch
Feb 11, 2000·Journal of Neurophysiology·K T MoortgatT J Sejnowski
Feb 11, 2000·Journal of Neurophysiology·K T MoortgatT J Sejnowski
Sep 5, 2019·Frontiers in Integrative Neuroscience·Michael G Metzen
Oct 9, 2020·Scientific Reports·Aaron R ShifmanJohn E Lewis
Mar 23, 2021·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Stefan MuchaRüdiger Krahe
Jun 14, 2013·The Journal of Experimental Biology·Kent D DunlapJames F Castellano
Nov 26, 2011·The Journal of Experimental Biology·Erin E ReardonLauren J Chapman
May 6, 2008·The Journal of Experimental Biology·Ginette J Hupé, John E Lewis

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