Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle

Medical Hypotheses
László G BorosGábor Somlyai

Abstract

The naturally occurring isotope of hydrogen ((1)H), deuterium ((2)H), could have an important biological role. Deuterium depleted water delays tumor progression in mice, dogs, cats and humans. Hydratase enzymes of the tricarboxylic acid (TCA) cycle control cell growth and deplete deuterium from redox cofactors, fatty acids and DNA, which undergo hydride ion and hydrogen atom transfer reactions. A model is proposed that emphasizes the terminal complex of mitochondrial electron transport chain reducing molecular oxygen to deuterium depleted water (DDW); this affects gluconeogenesis as well as fatty acid oxidation. In the former, the DDW is thought to diminish the deuteration of sugar-phosphates in the DNA backbone, helping to preserve stability of hydrogen bond networks, possibly protecting against aneuploidy and resisting strand breaks, occurring upon exposure to radiation and certain anticancer chemotherapeutics. DDW is proposed here to link cancer prevention and treatment using natural ketogenic diets, low deuterium drinking water, as well as DDW production as the mitochondrial downstream mechanism of targeted anti-cancer drugs such as Avastin and Glivec. The role of (2)H in biology is a potential missing link to the elusive c...Continue Reading

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Citations

Jun 8, 2017·Journal of Cellular Biochemistry·Ziv Radisavljevic
Feb 27, 2019·Current Pharmaceutical Biotechnology·Liliya V FedulovaStepan S Dzhimak
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tetiana HalenovaTatiana Pleteneva
Jan 23, 2020·International Journal of Molecular Sciences·Marianna CaterinoIlaria Campesi
Feb 29, 2020·Cancer Management and Research·Johannes KleemannStefan Kippenberger
Sep 15, 2019·Molecular & Cellular Proteomics : MCP·Xuepei ZhangRoman A Zubarev
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexander BasovStepan Dzhimak
Mar 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gábor SomlyaiMiklós Molnár
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexander BasovStepan Dzhimak
Oct 18, 2019·Frontiers in Endocrinology·Hong YuYongxi Song
Apr 7, 2020·Scientific Reports·Nishtha PandeyP K Vinod
Mar 25, 2017·Neuro-oncology·László G BorosGábor Somlyai
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Igor ZlatskiyAnton Syroeshkin
Jul 31, 2020·Scientific Reports·Nelida Elizabeth López-Palau, José Manuel Olais-Govea
Jan 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yasuyuki TamaiYoshiyuki Takei
Dec 1, 2019·Molecular & Cellular Proteomics : MCP·Xuepei ZhangRoman A Zubarev
Mar 25, 2021·Cancer Control : Journal of the Moffitt Cancer Center·László G BorosGábor Somlyai
Nov 21, 2021·Metabolomics : Official Journal of the Metabolomic Society·James C LechLászló G Boros

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