Submucosal fat accumulation in human colorectal tissue and its association with abdominal obesity and insulin resistance

United European Gastroenterology Journal
Seriko WadaSumio Kawata

Abstract

In addition to visceral fat, peripheral ectopic fat accumulation is suggested to play a role in the pathophysiology of metabolic syndrome, which is known to be associated with not only cardiovascular diseases and type 2 diabetes mellitus but also colorectal cancer. This study aims to clarify whether there is ectopic fat accumulation in human colorectal tissue in association with metabolic syndrome or its components such as abdominal obesity and insulin resistance. Lipid contents of colorectal tissue were measured in 27 patients with colorectal polyp excised endoscopically. In addition, lipid droplets were immunohistochemically estimated using anti-perilipin antibody in 32 patients with colorectal cancer resected surgically. Increasing tissue triglyceride/phospholipid ratio was associated with increasing body mass index, fasting plasma insulin level and homeostasis model assessment as an index of insulin resistance (HOMA-IR), and also decreasing serum adiponectin level. Lipid droplets were observed in the submucosal region of colorectal tissue. The amount of lipid droplets was associated with increasing body mass index, waist circumference and visceral fat area. This study showed the presence of submucosal fat accumulation in hu...Continue Reading

References

Jun 4, 1999·Seminars in Cell & Developmental Biology·C LondosA R Kimmel
Oct 20, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·X LuA R Kimmel
Dec 17, 2002·Diabetes Research and Clinical Practice·Akira KuroeYutaka Seino
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sayaka OtakeSumio Kawata
Jul 28, 2005·Chinese Journal of Digestive Diseases·Hiroyuki Ono
Feb 13, 2008·The American Journal of Clinical Nutrition·Edward Giovannucci
Mar 12, 2010·World Journal of Gastroenterology : WJG·Sayaka OtakeSumio Kawata
Dec 15, 2010·The American Journal of Clinical Nutrition·Swaroop PendyalaPeter R Holt
Jun 3, 2011·The Journal of Clinical Investigation·Andrew S GreenbergDouglas G Mashek
Jul 9, 2011·Journal of Atherosclerosis and Thrombosis·Yuji MatsuzawaTadashi Nakamura
Oct 24, 2012·Journal of Clinical Gastroenterology·Raxitkumar JinjuvadiaSuthat Liangpunsakul
May 17, 2014·World Journal of Gastroenterology : WJG·Silvia RiondinoFiorella Guadagni
Jul 19, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Soo Lim, James B Meigs
May 20, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Scott M Grundy

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Citations

Dec 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haichuan PengXiaolei Wang
Apr 20, 2021·European Journal of Gastroenterology & Hepatology·Felipe Ramos-ZabalaLuis Moreno-Almazán
Nov 5, 2021·Scientific Reports·Tim O NieuwenhuisMarc K Halushka

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