Submucosal injection solution for gastrointestinal tract endoscopic mucosal resection and endoscopic submucosal dissection.

Drug Design, Development and Therapy
Toshio UraokaTakahiro Fujii

Abstract

Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have provided new alternatives for minimally invasive treatment of gastrointestinal adenomas and early-stage cancers that involve a minimum risk of lymph-node metastasis. The use of submucosal injections is essential to the success of these endoscopic resection techniques. The "ideal" submucosal injection solution should provide a sufficiently high submucosal fluid cushion for safe and effective EMRs and ESDs while also preserving lesion tissue for accurate histopathological assessment. In the past, normal saline (NS) solution was commonly used for this purpose, but it is difficult to achieve the proper submucosal elevation and maintain the desired height with NS. Therefore, other safe and effective facilitative submucosal injection solutions have been developed that also take into account relevant cost-benefit considerations. This review examines recent advances in the development of effective submucosal injection solutions for use during endoscopic resections.

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Citations

Jul 28, 2010·Journal of Gastroenterology and Hepatology·Abby ConlinTakuji Gotoda
Aug 26, 2009·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Michael Bourke
May 2, 2012·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Toshio UraokaNaohisa Yahagi
Nov 29, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Neal MehtaAmit Bhatt
Apr 24, 2012·World Journal of Gastrointestinal Endoscopy·Noriaki MatsuiHiroto Kita
Nov 16, 2018·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Ignacio BonVicente Lorenzo-Zúñiga
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Apr 25, 2020·Journal of Clinical Medicine·Cristina Moles-ArandaJosé Antonio Morales-Molina
Jun 26, 2021·World Journal of Gastroenterology : WJG·Yu-Jer HsiaoYing-Chun Jheng

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Methods Mentioned

BETA
dissection
biopsy

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