Submyometrial vasopressin injection before microwave ablation of vascular-rich submucosal myomas: a preliminary case study

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Akira Tsuda, Yasushi Kanaoka

Abstract

Purpose: Vascular-rich myomas are resistant to treatment involving transcervical microwave myolysis. To overcome cooling by blood perfusion, we injected dilute vasopressin solution into the space between the myometrium and the surface of the vascular-rich myomas. Material and Methods: Seven outpatients [age (mean ± SD age), 44.9 ± 3.9 years] with a single symptomatic vascular-rich submucosal myoma measuring 4.2-9.2 cm (6.5 ± 2.5 cm) underwent transcervical microwave myolysis and microwave endometrial ablation. Before microwave irradiation, dilute vasopressin solution was injected into the space between the myometrium and the surface of the vascular-rich myoma. We assessed the changes in the volumes of the vascular-rich myomas and blood hemoglobin levels before and 3 and 6 months after treatment. In addition, improvements in menorrhagia and satisfaction after the operation were assessed using visual analog scales. Results: Submyometrial injection of dilute vasopressin effectively reduced the abundant blood flow. The vascular-rich myomas were necrotized and shrank significantly by 69.0% at 3 months and 72.4% at 6 months after the operation (p < .05). Blood hemoglobin levels significantly increased at 3 months (p < .01). In additi...Continue Reading

References

Feb 24, 2001·Lancet·E A Stewart
Feb 7, 2002·Journal of Vascular and Interventional Radiology : JVIR·Takeshi IshidaHironobu Nakamura
Sep 24, 2005·The Journal of Obstetrics and Gynaecology Research·Yasushi KanaokaOsamu Ishiko
Feb 14, 2009·The Journal of Obstetrics and Gynaecology Research·Yasushi KanaokaOsamu Ishiko
Jul 16, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jing ZhangXue Jiang
Mar 2, 2012·Reproductive Sciences·Mohamed Sabry, Ayman Al-Hendy
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Citations

Sep 18, 2021·Biomedical Physics & Engineering Express·Ghina ZiaPunit Prakash

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