PMID: 7516354Apr 1, 1994Paper

Subnormal albumin gene expression is associated with weight loss in immunodeficient/DNA-repair-impaired wasted mice

Journal of the American College of Nutrition
C R LibertinG E Woloschak

Abstract

Mice bearing the autosomal recessive mutation wst express a disease syndrome of immunodeficiency, neurologic dysfunction, increased sensitivity to the killing effects of ionizing radiation, and dramatic weight loss that begins at 21 days of age and progresses until death at 28-32 days of age. Because of the reported association between abnormal liver status and weight loss, we designed experiments to examine expression of a variety of liver-specific genes in wst/wst mice relative to littermates (wst/.) and parental strain (BCF1) controls. Animals were individually weighed from ages 21-28 days to determine relative weight comparisons between wst/wst mice and controls. Dot blot hybridizations were set up to quantitate the accumulation of transcripts specific for alpha-fetoprotein, albumin and other liver-specific gene products. These results showed a 67% reduction in albumin mRNA expression in livers derived from wst/wst mice relative to both controls. Expression of alpha-fetoprotein, as well as a variety of other liver-specific genes [secretory component (SC), metallothionein (MT-2), cytochrome P1-450 (Cyt P1-450), transferrin receptor (Tf Rec), tumor necrosis factor (TNF), and immune-associated antigen (Ia)], was unaffected. Th...Continue Reading

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Citations

Apr 8, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Brian Holinsworth, Jessica D Martin
Aug 29, 2013·Mycopathologia·Gérald LarcherJean-Philippe Bouchara

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