Abstract
Anemia is a common complication during interferon-ribavirin therapy for hepatitis C. While normally a fall in hematocrit in results in an exponential compensatory rise in erythropoietin, such that the correlation between hematocrit and erythropoietin is sharply negative, the erythropoietin response during interferon-ribavirin combination therapy is not known. We measured the hematocrit and erythropoietin levels before and after about 4 weeks of interferon-ribavirin therapy for hepatitis C (n = 43), and compared their relation to the normal human response to anemia. The hematocrit fell from an average pre-treatment level of 43.7 +/- 3.7% to 36.9 +/- 5 (P < 0.0001). The erythropoietin level rose from 14.5 +/- 15.1 to 58.5 +/- 94.1 units/L (P < 0.0001), indicating there was an adequate stimulus for erythropoietin release. The rise of erythropoietin was severely impaired in relation to the normal human response to a fall in hematocrit. Using the normal human response to anemia as the population line, for our population there was a significant difference in the slope of hematocrit (x) versus log10 erythropoietin (y) (-8.7 vs. -3.098 respectively, P < 0.001) and y-intercept (4.609 vs. 2.753 respectively, P < 0.001). The Bonferroni ad...Continue Reading
References
May 9, 1991·The New England Journal of Medicine·A J Erslev
Jun 14, 1990·The New England Journal of Medicine·C B MillerJ L Spivak
Jul 1, 1985·Life Sciences·M L HuieB A Naughton
Jun 2, 1989·JAMA : the Journal of the American Medical Association·J L SpivakT C Quinn
Oct 1, 1988·Arthritis and Rheumatism·M C HochbergJ L Spivak
Jan 1, 1995·Stem Cells·R T Means
May 1, 1994·The American Journal of the Medical Sciences·S B Krantz
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L ArmstrongH S Margolis
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L De FranceschiR Corrocher
Aug 31, 2000·Critical Care Medicine·H L Corwin, S B Krantz
Oct 5, 2001·Lancet·M P MannsJ K Albrecht
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna E GergelyFrançoise Lunel-Fabiani
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ray Kim
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrian M Di Bisceglie, Jay H Hoofnagle
Citations
Jan 27, 2009·Current Gastroenterology Reports·Hans L TillmannJohn G McHutchison
Sep 18, 2014·BMC Infectious Diseases·Ahmad AmanzadaSabine Mihm
Jan 1, 2010·Mediterranean Journal of Hematology and Infectious Diseases·Paola MancinoJacopo Vecchiet
Jul 14, 2010·Seminars in Hematology·Hans L Tillmann, John G McHutchison
Apr 25, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·John G McHutchisonDan L Longo
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masatoshi IshigamiHidemi Goto
Dec 2, 2009·Journal of Medical Virology·Katia FalascaJacopo Vecchiet
Jan 26, 2005·The American Journal of Gastroenterology·Vijayan BalanUNKNOWN HCV Natural History Study Group
Jun 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sammy SaabRonald W Busuttil
Aug 24, 2010·European Journal of Gastroenterology & Hepatology·Lotte G Van VlerkenKarel J Van Erpecum