Suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir

The Journal of Antimicrobial Chemotherapy
Pablo Barreiro, Vincent Soriano

Abstract

The combination of nucleos(t)ide analogues (NAs) is essential for the design of effective antiretroviral regimens. Although there are currently many options for the selection of such drug backbones, not all combinations display optimal results. As the number of these compounds has increased, it has become clear that the concomitant administration of certain NAs should be avoided due to high rates of toxicity and/or greater risk of virological failure. As an example, the combination of didanosine and tenofovir has recently been associated with a paradoxical depletion of CD4+ T cells in the face of complete viral suppression. Interference between the pathways leading to the intracellular activation of didanosine and tenofovir, and their blocking of the purine nucleoside phosphorylase, seems to explain this phenomenon.

References

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Jun 26, 2004·Clinical Pharmacokinetics·Brian P KearneyJaymin Shah

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Citations

May 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alan WinstonSean Emery
Feb 12, 2009·The Pediatric Infectious Disease Journal·Andrew RiordanUNKNOWN Collaborative HIV Paediatric Study
Feb 9, 2012·The Indian Journal of Medical Research·N KumarasamySanjay Pujari
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Dec 7, 2007·Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria·P AmarilesM J Faus

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