Suboptimal cytoreduction in ovarian carcinoma is associated with molecular pathways characteristic of increased stromal activation

Gynecologic Oncology
Zhenqiu LiuSandra Orsulic

Abstract

Suboptimal cytoreductive surgery in advanced epithelial ovarian cancer (EOC) is associated with poor survival but it is unknown if poor outcome is due to the intrinsic biology of unresectable tumors or insufficient surgical effort resulting in residual tumor-sustaining clones. Our objective was to identify the potential molecular pathway(s) and cell type(s) that may be responsible for suboptimal surgical resection. By comparing gene expression in optimally and suboptimally cytoreduced patients, we identified a gene network associated with suboptimal cytoreduction and explored the biological processes and cell types associated with this gene network. We show that primary tumors from suboptimally cytoreduced patients express molecular signatures that are typically present in a distinct molecular subtype of EOC characterized by increased stromal activation and lymphovascular invasion. Similar molecular pathways are present in EOC metastases, suggesting that primary tumors in suboptimally cytoreduced patients are biologically similar to metastatic tumors. We demonstrate that the suboptimal cytoreduction network genes are enriched in reactive tumor stroma cells rather than malignant tumor cells. Our data suggest that the success of ...Continue Reading

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Citations

Jun 24, 2016·Gynecologic Oncology·Beyhan AtasevenAndreas du Bois
Dec 7, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Edward J TannerDennis S Chi
Dec 7, 2017·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Neville F Hacker
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Beyhan AtasevenFlorian Heitz
Sep 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Eduardo PaulinoPaul E Goss
Apr 16, 2020·American Journal of Reproductive Immunology : AJRI·Agata MlynskaVita Pašukonienė
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Ye HuSandra Orsulic
Mar 11, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chen WangEllen L Goode
Nov 2, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katelyn F Handley, Anil K Sood
Mar 9, 2021·Critical Reviews in Oncology/hematology·D Lorusso, G Daniele
Jul 10, 2020·Gynecologic Oncology·Katharine K BriegerUNKNOWN Ovarian Cancer Association Consortium
May 7, 2021·American Journal of Obstetrics and Gynecology·Benjamin B AlbrightRebecca A Previs

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