Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study

The Journal of Nutrition
Marianne H AbelAnne-Lise Brantsæter

Abstract

Background: Severe iodine deficiency in pregnancy has major effects on child neurodevelopment, but less is known about the potential consequences of mild-to-moderate deficiency and iodine supplement use.Objective: We explored the associations between maternal iodine intake and child neurodevelopment at 3 y of age and the potential impact of maternal intake of iodine from supplements on the same outcomes.Methods: This population-based prospective observational study included 48,297 mother-child pairs recruited during pregnancy from 2002 to 2008. Maternal iodine intake was calculated based on a validated food-frequency questionnaire answered during midpregnancy that covered mean intake since the beginning of pregnancy. Associations between iodine intake and maternal-reported child language and motor development and behavior problems were explored by multivariable regression analyses.Results: In 33,047 mother-child pairs, excluding iodine supplement users, maternal iodine intake was associated with child language delay (P = 0.024), externalizing and internalizing behavior problems (both P < 0.001), and fine motor skills (P = 0.002) but not gross motor skills or the risk of not walking unaided at 17 mo of age. In 74% of the partici...Continue Reading

Citations

Mar 2, 2018·Nutrients·Inés VelascoMargaret P Rayman
Mar 3, 2018·Nutrients·Sigrun HenjumAnne Lise Brantsæter
Jan 18, 2018·Nutrients·Abby G ErshowPamela R Pehrsson
Jun 2, 2018·Thyroid : Official Journal of the American Thyroid Association·Yaniv S OvadiaAron M Troen
Aug 23, 2018·Thyroid : Official Journal of the American Thyroid Association·Marianne Hope AbelAnne Lise Brantsæter
Nov 20, 2018·American Journal of Epidemiology·Shao J ZhouMaria Makrides
Jan 16, 2019·The Proceedings of the Nutrition Society·Sarah C Bath
Jan 30, 2018·Nutrition & Metabolism·Julie Bienertová-VaškůHynek Pikhart
Sep 30, 2018·Thyroid : Official Journal of the American Thyroid Association·Aneesh PatelElizabeth N Pearce
Sep 16, 2018·Biological Trace Element Research·Wei ZhaoCheng Han
Mar 5, 2019·Clinical Obstetrics and Gynecology·Sanjita B Chittimoju, Elizabeth N Pearce
Oct 11, 2019·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Jill SherriffSheila Skeaff
Jan 12, 2020·Nutrition Reviews·Benjamin Brown, Ciara Wright
Jul 1, 2020·Maternal & Child Nutrition·Inger AakreMaria Wik Markhus
May 15, 2018·The Journal of Clinical Endocrinology and Metabolism·Deborah LevieMònica Guxens
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Aug 25, 2020·Maternal & Child Nutrition·Karen CodlingJonathan Gorstein
Apr 7, 2019·Current Nutrition Reports·Davide Mattei, Angelo Pietrobelli
Nov 30, 2019·Hormones : International Journal of Endocrinology and Metabolism·Hossein Delshad, Fereidoun Azizi
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Oct 4, 2018·Biological Trace Element Research·Yanting ChenWanqi Zhang
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Aug 5, 2020·Thyroid : Official Journal of the American Thyroid Association·Maria Wik MarkhusMarian Kjellevold
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